Contrasting Effects of B Cell Depletion on CD4 and CD8 Memory T Cell Responses Generated After Transplantation

Overview

Journal Am J Transplant

Publisher Elsevier

Specialty General Surgery

Date 2020 Mar 19

PMID 32185859

Citations 4

Authors

Jose Marino

Bruno Gonzalez-Nolasco

Xianding Wang

William Orent

Gilles Benichou

Affiliations

Soon will be listed here.

Abstract

Alloreactive memory T cells play a key role in transplantation by accelerating allograft rejection and preventing tolerance induction. Some studies using µMT mice, which are constitutionally devoid of B cells, showed that B cells were required for the generation of memory T cells after allotransplantation. However, whether B cell depletion in normal adult mice has the same effect on memory responses by CD4 and CD8 T cells activated after transplantation has not been thoroughly investigated. In this study, we tested the effect of anti-CD20 antibody-mediated B cell depletion on CD4 and CD8 memory T cell alloresponses after skin transplantation in wild-type mice. We found that B cell depletion prevented the development of memory alloresponses by CD4 T cells but enhanced that of CD8 memory T cells. Next, we tested the influence of B cell depletion on hematopoietic chimerism. In OT-II CD4 anti-OVA TCR transgenic mice sensitized to ovalbumin antigen, B cell depletion also impaired allospecific memory T cell responses and thereby enhanced donor hematopoietic chimerism and T cell deletion after bone marrow transplantation. This study underscores the complexity of the relationships between B and T cells in the generation and reactivation of different memory T cell subsets after transplantation.

Citing Articles

The Entangled World of Memory T Cells and Implications in Transplantation.

Alexander K, Ford M Transplantation. 2023; 108(1):137-147.

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B cell depletion with anti-CD20 mAb exacerbates anti-donor CD4 T cell responses in highly sensitized transplant recipients.

Tanaka A, Ide K, Tanaka Y, Ohira M, Tahara H, Ohdan H Sci Rep. 2021; 11(1):18180.

PMID: 34518640 PMC: 8437972. DOI: 10.1038/s41598-021-97748-9.

Properties of regulatory B cells regulating B cell targets.

Fu Q, Lee K, Huai G, Deng K, Agarwal D, Rickert C Am J Transplant. 2021; 21(12):3847-3857.

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