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William O Ogle

Explore the profile of William O Ogle including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Barish P, Xu Y, Li J, Sun J, Jarajapu Y, Ogle W
Eur J Pharmacol . 2013 Mar; 705(1-3):42-8. PMID: 23454521
The use of opioids, which achieve therapeutic analgesia through activation of μ-opioid receptors, are limited in the management of chronic pain by adverse effects including tolerance and addiction. Optogenetics is...
2.
Ogle W, Speisman R, Ormerod B
Gerontology . 2012 Sep; 59(1):23-31. PMID: 22947921
A variety of consumable plant-derived phytochemicals exhibit nutraceutical properties because they produce physiological benefits and combat disease processes. Emerging evidence suggests that widely accessible and safe organic polyphenolic phytochemicals, in...
3.
Xu Y, Barish P, Pan J, Ogle W, ODonnell J
Methods Mol Biol . 2012 Jan; 829:103-24. PMID: 22231809
Depression is among the most prevalent forms of mental illness and a major cause of morbidity worldwide. Diagnosis of depression is mainly based on symptomatic criteria, and the heterogeneity of...
4.
Boykin E, Khargonekar P, Carney P, Ogle W, Talathi S
J Comput Neurosci . 2011 Oct; 32(3):521-38. PMID: 21997131
The application of data-driven time series analysis techniques such as Granger causality, partial directed coherence and phase dynamics modeling to estimate effective connectivity in brain networks has recently gained significant...
5.
Xu Y, Li S, Vernon M, Pan J, Chen L, Barish P, et al.
J Neurochem . 2011 Jun; 118(5):784-95. PMID: 21689105
Curcumin, a major active component of Curcuma longa, possesses antioxidant and neuroprotective activities. The present study explores the mechanisms underlying the neuroprotective effect of curcumin against corticosterone and its relation...
6.
Zeier Z, Madorsky I, Xu Y, Ogle W, Notterpek L, Foster T
Mech Ageing Dev . 2010 Nov; 132(1-2):8-19. PMID: 21055414
We measured changes in gene expression, induced by aging and caloric restriction (CR), in three hippocampal subregions. When analysis included all regions, aging was associated with expression of genes linked...
7.
Boykin E, Ogle W
Mol Biosyst . 2010 Jul; 6(10):1993-2003. PMID: 20672180
Experimental data from biological pathways come in many forms: qualitative or quantitative, static or dynamic. By combining a variety of these heterogeneous sources of data, we construct a mathematical model...
8.
Xu Y, Wang Z, You W, Zhang X, Li S, Barish P, et al.
Eur Neuropsychopharmacol . 2010 Apr; 20(6):405-13. PMID: 20353885
The antidepressant-like effect of trans-resveratrol, a phenolic compound present in polygonum cuspidatum, was evaluated through behavioral and neurochemical methods. trans-Resveratrol (20, 40 and 80 mg/kg, via gavage) significantly decreased the...
9.
Xu Y, Li S, Chen R, Li G, Barish P, You W, et al.
Pharmacol Biochem Behav . 2009 Oct; 94(3):447-53. PMID: 19857512
Proanthocyanidin is a phenolic product present in plants which has antioxidant, antinociceptive and neuroprotective properties, without inducing significant toxicological effects. The present study tested the hypothesis that low molecular proanthocyanidin...
10.
Xu Y, Lin D, Li S, Li G, Shyamala S, Barish P, et al.
Neuropharmacology . 2009 Jun; 57(4):463-71. PMID: 19540859
Chronic stress occurs in everyday life and induces impaired spatial cognition, neuroendocrine and plasticity abnormalities. A potential therapeutic for these stress related disturbances is curcumin, derived from the curry spice...