James M ODonnell
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Explore the profile of James M ODonnell including associated specialties, affiliations and a list of published articles.
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69
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1913
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Recent Articles
1.
Yan Y, Gao S, Avasthi S, Zhao Y, Ye J, Tao Y, et al.
Neuropharmacology
. 2022 May;
213:109128.
PMID: 35588859
Our previous study suggested that inhibition of Phosphodiesterase 2 ameliorates memory loss upon exposure to oxidative stress. While whether memory enhancing effects of PDE2 inhibition on Alzheimer's disease mouse model...
2.
Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak S, et al.
Mol Neurodegener
. 2021 Oct;
16(1):70.
PMID: 34593014
Background: N6-methyladenosine (mA) modification of RNA influences fundamental aspects of RNA metabolism and mA dysregulation is implicated in various human diseases. In this study, we explored the potential role of...
3.
Wang Y, Gao S, Zheng V, Chen L, Ma M, Shen S, et al.
Front Cell Dev Biol
. 2020 Dec;
8:599389.
PMID: 33363155
A global, quantitative proteomics/systems-biology analysis of the selective pharmacological inhibition of phosphodiesterase-4D (PDE4D) revealed the differential regulation of pathways associated with neuroplasticity in memory-associated brain regions. Subtype selective inhibitors of...
4.
Zhu M, Shi J, Chen Y, Huang G, Zhu X, Zhang S, et al.
Psychopharmacology (Berl)
. 2020 Sep;
237(11):3215-3224.
PMID: 32926224
Rationale: Currently available PDE2 inhibitors have poor brain penetration that limits their therapeutic utility in the treatment of depression. Hcyb1 is a novel selective PDE2 inhibitor that was introduced more...
5.
ODonnell J, Anand S, Brown S, Fuji K, Guy R, Kawaguchi-Suzuki M, et al.
Am J Pharm Educ
. 2020 Feb;
83(10):7595.
PMID: 32001891
The 2018-2019 Research and Graduate Affairs Committee (RGAC) was charged with critically evaluating the leadership development support necessary for pharmacy researchers, including postdoctoral trainees, to develop the skills needed to...
6.
Cui S, Yang M, Zhang Y, Zheng V, Zhang H, Gurney M, et al.
J Pharmacol Exp Ther
. 2019 Sep;
371(2):250-259.
PMID: 31488603
Recent imaging studies of amyloid and tau in cognitively normal elderly subjects imply that Alzheimer's pathology can be tolerated by the brain to some extent due to compensatory mechanisms operating...
7.
Liu N, Wang Y, An A, Banker C, Qian Y, ODonnell J
Eur J Neurosci
. 2019 Sep;
52(1):2694-2704.
PMID: 31471985
Single-housed stress elicits a range of social isolation-related behavioral and neurobiological abnormalities. To investigate single housing-induced behavioral changes and sex differences on stress outcomes, we examined single-housed stress-induced learning and...
8.
Zhu X, Li W, Li Y, Xu W, Yuan Y, Zheng V, et al.
Neuropharmacology
. 2019 Apr;
153:20-31.
PMID: 31026437
Resveratrol is a natural non-flavonoid polyphenol found in red wine, which has numerous pharmacological properties including anti-stress and antidepressant-like abilities. However, whether the antidepressant- and anxiolytic-like effects of resveratrol are...
9.
Gurney M, Nugent R, Mo X, Sindac J, Hagen T, Fox 3rd D, et al.
J Med Chem
. 2019 Apr;
62(10):4884-4901.
PMID: 31013090
Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that...
10.
Chen L, Cui S, Yu H, Li G, Liu N, Wu Q, et al.
J Psychopharmacol
. 2019 Mar;
33(5):568-576.
PMID: 30835157
Background: Phosphodiesterase-2 (PDE2) is a cyclic nucleotide phosphodiesterase and is highly expressed in the amygdala, which suggests its important role in anxiety-like behavior. Aims: The present study examined whether reduced...