William J Boyle
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Explore the profile of William J Boyle including associated specialties, affiliations and a list of published articles.
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12
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3499
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Recent Articles
1.
Frey G, Cugnetti A, Liu H, Xing C, Wheeler C, Chang H, et al.
MAbs
. 2024 Mar;
16(1):2322562.
PMID: 38445633
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that plays several roles in cancer biology. EpCAM is an attractive therapeutic target because of its expression in most solid tumors....
2.
Chang H, Frey G, Liu H, Xing C, Steinman L, Boyle W, et al.
Proc Natl Acad Sci U S A
. 2021 Feb;
118(9).
PMID: 33627407
Anticytotoxic T lymphocyte-associated protein 4 (CTLA4) antibodies have shown potent antitumor activity, but systemic immune activation leads to severe immune-related adverse events, limiting clinical usage. We developed novel, conditionally active...
3.
Bowers P, Boyle W, Damoiseaux R
Methods Mol Biol
. 2018 Sep;
1827:479-489.
PMID: 30196512
The engineering of antibodies and antibody fragments for affinity maturation, stability, and other biophysical characteristics is a common aspect of therapeutic development. Maturation of antibodies in B cells during the...
4.
Lacey D, Boyle W, Simonet W, Kostenuik P, Dougall W, Sullivan J, et al.
Nat Rev Drug Discov
. 2012 May;
11(5):401-19.
PMID: 22543469
Bone is a complex tissue that provides mechanical support for muscles and joints, protection for vital organs, a mineral reservoir that is essential for calcium homeostasis, and the environment and...
5.
Bowers P, Horlick R, Neben T, Toobian R, Tomlinson G, Dalton J, et al.
Proc Natl Acad Sci U S A
. 2011 Dec;
108(51):20455-60.
PMID: 22158898
A novel approach has been developed for the isolation and maturation of human antibodies that replicates key features of the adaptive immune system by coupling in vitro somatic hypermutation (SHM)...
6.
Bornstein G, Klakamp S, Andrews L, Boyle W, Tabrizi M
Drug Discov Today
. 2009 Oct;
14(23-24):1159-65.
PMID: 19853060
When cross-reactivity of a lead antibody across species is limited, antibody development programs require the generation of surrogate molecules or surrogate animal models necessary for the conduct of preclinical pharmacology...
7.
Kostenuik P, Nguyen H, McCabe J, Warmington K, Kurahara C, Sun N, et al.
J Bone Miner Res
. 2008 Nov;
24(2):182-95.
PMID: 19016581
RANKL is a TNF family member that mediates osteoclast formation, activation, and survival by activating RANK. The proresorptive effects of RANKL are prevented by binding to its soluble inhibitor osteoprotegerin...
8.
Kwak K, Zhou X, Solomon V, Baracos V, Davis J, Bannon A, et al.
Cancer Res
. 2004 Nov;
64(22):8193-8.
PMID: 15548684
The progressive depletion of skeletal muscle is a hallmark of many types of advanced cancer and frequently is associated with debility, morbidity, and mortality. Muscle wasting is primarily mediated by...
9.
Boyle W, Simonet W, Lacey D
Nature
. 2003 May;
423(6937):337-42.
PMID: 12748652
Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular...
10.
Eghbali-Fatourechi G, Khosla S, Sanyal A, Boyle W, Lacey D, Riggs B
J Clin Invest
. 2003 Apr;
111(8):1221-30.
PMID: 12697741
Studies in rodents have implicated various cytokines as paracrine mediators of increased osteoclastogenesis during estrogen deficiency, but increases in RANKL, the final effector of osteoclastogenesis, have not been demonstrated. Thus,...