William G Dunphy
Overview
Explore the profile of William G Dunphy including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
40
Citations
2167
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Haccard O, Ciardo D, Narrissamprakash H, Bronchain O, Kumagai A, Dunphy W, et al.
Commun Biol
. 2023 Jul;
6(1):788.
PMID: 37516798
Metazoan genomes are duplicated by the coordinated activation of clusters of replication origins at different times during S phase, but the underlying mechanisms of this temporal program remain unclear during...
2.
Zhang Y, Shen B, Wu T, Zhao J, Jing J, Wang P, et al.
Nat Commun
. 2022 Sep;
13(1):5247.
PMID: 36068212
Many ultrafast phenomena in biology and physics are fundamental to our scientific understanding but have not yet been visualized owing to the extreme speed and sensitivity requirements in imaging modalities....
3.
Dunphy W
Mol Cell
. 2021 Mar;
81(6):1126-1127.
PMID: 33740471
Frattini et al. (2021) demonstrate that TopBP1 forms phase-separated nuclear condensates to promote activation of ATR in cells experiencing genomic stress.
4.
Kumagai A, Dunphy W
Cell Rep
. 2020 Sep;
32(12):108178.
PMID: 32966791
The processes that control where higher eukaryotic cells initiate DNA replication throughout the genome are not understood clearly. In metazoans, the Treslin-MTBP complex mediates critical final steps in formation of...
5.
Lim D, Joukov V, Rettenmaier T, Kumagai A, Dunphy W, Wells J, et al.
Sci Signal
. 2020 Jul;
13(641).
PMID: 32694171
Cell cycle-dependent redox changes can mediate transient covalent modifications of cysteine thiols to modulate the activities of regulatory kinases and phosphatases. Our previously reported finding that protein cysteine oxidation is...
6.
Lyu K, Kumagai A, Dunphy W
Cell Cycle
. 2019 Apr;
18(8):898-913.
PMID: 30975033
Besides TopBP1, ETAA1 has been identified more recently as an activator of the ATR-ATRIP complex in human cells. We have examined the role of ETAA1 in the Xenopus egg-extract system,...
7.
Kumagai A, Dunphy W
Mol Biol Cell
. 2017 Sep;
28(22):2998-3012.
PMID: 28877985
Treslin, which is essential for incorporation of Cdc45 into the replicative helicase, possesses a partner called MTBP (Mdm2-binding protein). We have analyzed and human MTBP to assess its role in...
8.
Mu R, Tat J, Zamudio R, Zhang Y, Yates 3rd J, Kumagai A, et al.
Mol Cell Biol
. 2017 Jul;
37(20).
PMID: 28739856
CKS proteins are small (9-kDa) polypeptides that bind to a subset of the cyclin-dependent kinases. The two paralogs expressed in mammals, Cks1 and Cks2, share an overlapping function that is...
9.
Ryu H, Yoshida M, Sridharan V, Kumagai A, Dunphy W, Dasso M, et al.
Cell Cycle
. 2015 Jul;
14(17):2777-84.
PMID: 26131587
DNA topoisomerase II (TopoII) regulates DNA topology by its strand passaging reaction, which is required for genome maintenance by resolving tangled genomic DNA. In addition, TopoII contributes to the structural...
10.
Guo C, Kumagai A, Schlacher K, Shevchenko A, Shevchenko A, Dunphy W
Mol Cell
. 2015 Jan;
57(3):492-505.
PMID: 25557548
Treslin helps to trigger the initiation of DNA replication by promoting integration of Cdc45 into the replicative helicase. Treslin is a key positive-regulatory target of cell-cycle control mechanisms; activation of...