William F Westlin
Overview
Explore the profile of William F Westlin including associated specialties, affiliations and a list of published articles.
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27
Citations
1154
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Recent Articles
1.
Petitpas K, Habibabady Z, Ritchie V, Connolly M, Burdorf L, Qin W, et al.
Xenotransplantation
. 2022 Sep;
29(6):e12780.
PMID: 36125388
The phenomenon of diminishing hematocrit after in vivo liver and lung xenotransplantation and during ex vivo liver xenoperfusion has largely been attributed to action by resident liver porcine macrophages, which...
2.
Ma D, Hirose T, Lassiter G, Sasaki H, Rosales I, Coe T, et al.
Am J Transplant
. 2021 Jul;
22(1):46-57.
PMID: 34331749
Porcine cells devoid of three major carbohydrate xenoantigens, αGal, Neu5GC, and SDa (TKO) exhibit markedly reduced binding of human natural antibodies. Therefore, it is anticipated that TKO pigs will be...
3.
Yue Y, Xu W, Kan Y, Zhao H, Zhou Y, Song X, et al.
Nat Biomed Eng
. 2020 Sep;
5(2):134-143.
PMID: 32958897
The clinical applicability of porcine xenotransplantation-a long-investigated alternative to the scarce availability of human organs for patients with organ failure-is limited by molecular incompatibilities between the immune systems of pigs...
4.
Improgo M, Tesar B, Klitgaard J, Magori-Cohen R, Yu L, Kasar S, et al.
Br J Haematol
. 2018 Dec;
184(6):925-936.
PMID: 30537114
The L265P somatic mutation in the Myeloid Differentiation Primary Response 88 (MYD88) gene is a recurrent mutation in chronic lymphocytic leukaemia (CLL). This mutation has functional effects in various haematological...
5.
Lally J, Ghoshal S, DePeralta D, Moaven O, Wei L, Masia R, et al.
Cell Metab
. 2018 Sep;
29(1):174-182.e5.
PMID: 30244972
The incidence of hepatocellular carcinoma (HCC) is rapidly increasing due to the prevalence of obesity and non-alcoholic fatty liver disease, but the molecular triggers that initiate disease development are not...
6.
Stiede K, Miao W, Blanchette H, Beysen C, Harriman G, Harwood Jr H, et al.
Hepatology
. 2017 May;
66(2):324-334.
PMID: 28470676
Conclusion: ACC inhibition with a single dose of NDI-010976 is well tolerated and results in a profound dose-dependent inhibition of hepatic DNL in overweight adult male subjects. Therefore, NDI-010976 could...
7.
Svensson R, Parker S, Eichner L, Kolar M, Wallace M, Brun S, et al.
Nat Med
. 2016 Sep;
22(10):1108-1119.
PMID: 27643638
Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is controlled by the...
8.
Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, et al.
Proc Natl Acad Sci U S A
. 2016 Mar;
113(13):E1796-805.
PMID: 26976583
Simultaneous inhibition of the acetyl-CoA carboxylase (ACC) isozymes ACC1 and ACC2 results in concomitant inhibition of fatty acid synthesis and stimulation of fatty acid oxidation and may favorably affect the...
9.
Kelly P, Romero D, Yang Y, Shaffer 3rd A, Chaudhary D, Robinson S, et al.
J Exp Med
. 2015 Dec;
212(13):2189-201.
PMID: 26621451
Pathological activation of the Toll-like receptor signaling adaptor protein MYD88 underlies many autoimmune and inflammatory disease states. In the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma...
10.
Deng H, Bernier S, Doyle E, Lorusso J, Morgan B, Westlin W, et al.
ACS Med Chem Lett
. 2014 Jun;
4(10):942-7.
PMID: 24900589
To develop effective oral treatment for multiple sclerosis (MS), we discovered a series of alkyl-substituted biaryl amino alcohols as selective S1P1 modulators. One exemplar is (S)-2-amino-2-(5-(4-(octyloxy)-3-(trifluoromethyl)phenyl)-1,3,4-thiadiazol-2-yl)propan-1-ol (10, GSK1842799). Upon phosphorylation,...