William Beggs
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Explore the profile of William Beggs including associated specialties, affiliations and a list of published articles.
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22
Citations
762
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Recent Articles
1.
McQuillan M, Verhulst S, Hansen M, Beggs W, Meskel D, Belay G, et al.
Am J Hum Genet
. 2024 May;
111(5):927-938.
PMID: 38701745
Leukocyte telomere length (LTL) varies significantly across human populations, with individuals of African ancestry having longer LTL than non-Africans. However, the genetic and environmental drivers of LTL variation in Africans...
2.
Pagkrati I, Duke J, Mbunwe E, Mosbruger T, Ferriola D, Wasserman J, et al.
HLA
. 2023 Mar;
102(2):192-205.
PMID: 36999238
HLA allelic variation has been well studied and documented in many parts of the world. However, African populations have been relatively under-represented in studies of HLA variation. We have characterized...
3.
Fan S, Spence J, Feng Y, Hansen M, Terhorst J, Beltrame M, et al.
Cell
. 2023 Mar;
186(5):923-939.e14.
PMID: 36868214
We conduct high coverage (>30×) whole-genome sequencing of 180 individuals from 12 indigenous African populations. We identify millions of unreported variants, many predicted to be functionally important. We observe that...
4.
Kelly D, Ramdas S, Ma R, Rawlings-Goss R, Grant G, Ranciaro A, et al.
Genome Biol
. 2023 Feb;
24(1):35.
PMID: 36829244
Background: Mapping of quantitative trait loci (QTL) associated with molecular phenotypes is a powerful approach for identifying the genes and molecular mechanisms underlying human traits and diseases, though most studies...
5.
McQuillan M, Ranciaro A, Hansen M, Fan S, Beggs W, Belay G, et al.
Mol Biol Evol
. 2022 Aug;
39(10).
PMID: 36026493
The alcohol dehydrogenase (ADH) family of genes encodes enzymes that catalyze the metabolism of ethanol into acetaldehyde. Nucleotide variation in ADH genes can affect the catalytic properties of these enzymes...
6.
Zhang C, Verma A, Feng Y, Melo M, McQuillan M, Hansen M, et al.
Proc Natl Acad Sci U S A
. 2022 May;
119(21):e2123000119.
PMID: 35580180
Human genomic diversity has been shaped by both ancient and ongoing challenges from viruses. The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
7.
Zhang C, Verma A, Feng Y, Dos Reis Melo M, McQuillan M, Hansen M, et al.
Res Sq
. 2021 Aug;
PMID: 34341784
We investigated global patterns of genetic variation and signatures of natural selection at host genes relevant to SARS-CoV-2 infection ( , and ). We analyzed novel data from 2,012 ethnically...
8.
Zhang C, Verma A, Feng Y, Melo M, McQuillan M, Hansen M, et al.
medRxiv
. 2021 Jul;
PMID: 34230933
We investigated global patterns of genetic variation and signatures of natural selection at host genes relevant to SARS-CoV-2 infection (, , , and ). We analyzed novel data from 2,012...
9.
Hunt S, Hansen M, Verhulst S, McQuillan M, Beggs W, Lai T, et al.
Hum Mol Genet
. 2020 Aug;
29(18):3014-3020.
PMID: 32821950
Leukocyte telomere length (LTL) might be causal in cardiovascular disease and major cancers. To elucidate the roles of genetics and geography in LTL variability across humans, we compared LTL measured...
10.
Fan S, Kelly D, Beltrame M, Hansen M, Mallick S, Ranciaro A, et al.
Genome Biol
. 2019 Oct;
20(1):204.
PMID: 31597575
Following publication of the original article [1], a typographical error in the formula for calculating d in the "Scans for local adaptation" subsection in the Method section, was identified. The...