Wilfred Chen
Overview
Explore the profile of Wilfred Chen including associated specialties, affiliations and a list of published articles.
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Articles
191
Citations
1988
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Recent Articles
1.
Chen W, Sullivan M
Curr Opin Biotechnol
. 2024 Oct;
90:103214.
PMID: 39388800
No abstract available.
2.
Stohr A, Ma D, Chen W, Blenner M
Biotechnol Adv
. 2024 Sep;
77:108457.
PMID: 39343083
Conditional protein-protein interactions enable dynamic regulation of cellular activity and are an attractive approach to probe native protein interactions, improve metabolic engineering of microbial factories, and develop smart therapeutics. Conditional...
3.
Tang J, Becker M, Lenhoff A, Chen W
Biotechnol Bioeng
. 2024 Sep;
121(12):3860-3868.
PMID: 39279211
Affinity precipitation is a powerful separation method in that it combines the binding selectivity of affinity chromatography with precipitation of captured biomolecules via phase separation triggered by small changes in...
4.
Cassel S, Huntington B, Chen W, Lei P, Andreadis S, Kloxin A
APL Bioeng
. 2024 Jun;
8(2):026127.
PMID: 38938687
Activation of fibroblasts is pivotal for wound healing; however, persistent activation leads to maladaptive processes and is a hallmark of fibrosis, where disease mechanisms are only partially understood. Human model...
5.
Yang H, Chen W
ACS Synth Biol
. 2024 Jun;
13(7):2073-2080.
PMID: 38889440
BioPROTACs are heterobifunctional proteins designed for targeted protein degradation. While they offer a potential therapeutic avenue for modulating disease-related proteins, the current strategies are static in nature and lack the...
6.
Richards B, Goncalves A, Sullivan M, Chen W
Curr Opin Biotechnol
. 2024 Feb;
86:103070.
PMID: 38354452
Protein nanoparticles offer a highly tunable platform for engineering multifunctional drug delivery vehicles that can improve drug efficacy and reduce off-target effects. While many protein nanoparticles have demonstrated the ability...
7.
Sullivan M, Chen W
Methods Mol Biol
. 2023 Sep;
2720:177-189.
PMID: 37775666
Naturally occurring protein nanocages are promising drug carriers as both the interior and exterior can be decorated for drug encapsulation and cell targeting. To provide surface functionalization, we added a...
8.
Chen W, Sullivan M
Methods Mol Biol
. 2023 Sep;
2720:151-164.
PMID: 37775664
Protein drugs are a critically important therapeutic modality due to the sophisticated binding recognition, catalytic properties, and disease relevance of proteins. There is a clear need for new strategies able...
9.
Sullivan M, Chen W
Methods Mol Biol
. 2023 Sep;
2720:115-126.
PMID: 37775661
Nature provides an abundance of proteins whose structures and reactivity have been perfected through evolution to perform specific tasks necessary for biological function. The structural and functional properties of many...
10.
Besada-Lombana P, Chen W, Da Silva N
Biotechnol Bioeng
. 2023 Sep;
121(1):403-408.
PMID: 37749915
The efficient hydrolysis of lignocellulosic biomass into fermentable sugars is key for viable economic production of biofuels and biorenewable chemicals from second-generation feedstocks. Consolidated bioprocessing (CBP) combines lignocellulose saccharification and...