Wilfred Chen
Overview
Explore the profile of Wilfred Chen including associated specialties, affiliations and a list of published articles.
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Articles
191
Citations
1988
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Recent Articles
11.
Yur D, Sullivan M, Chen W
J Mater Chem B
. 2023 Apr;
11(18):3985-3993.
PMID: 37083736
Protein therapeutics offer enormous clinical impact in treating a variety of diseases by offering high selectivity with limited off-target effects. However, delivery challenges severely hinder functional proteins from reaching their...
12.
Pham A, Bassett S, Chen W, Da Silva N
ACS Synth Biol
. 2023 Mar;
12(4):1164-1174.
PMID: 36920425
Cells often localize pathway enzymes in close proximity to reduce substrate loss via diffusion and to ensure that carbon flux is directed toward the desired product. To emulate this strategy...
13.
Tsai S, Sun Q, Chen W
Curr Opin Biotechnol
. 2023 Jan;
80:102890.
PMID: 36689851
No abstract available.
14.
Tsai S, Sun Q, Chen W
Curr Opin Biotechnol
. 2022 Nov;
78:102840.
PMID: 36356377
The primary obstacle impeding the more widespread use of biomass for energy and chemical production is the absence of a low-cost technology for overcoming their recalcitrant nature. It has been...
15.
Goncalves A, Hartzell E, Sullivan M, Chen W
Adv Drug Deliv Rev
. 2022 Oct;
191:114570.
PMID: 36228897
Currently, there are over 100 antibody-based therapeutics on the market for the treatment of various diseases. The increasing importance of antibody treatment is further highlighted by the recent FDA emergency...
16.
Chen R, Chen W
ACS Synth Biol
. 2022 Jul;
11(8):2719-2725.
PMID: 35816756
The programmability of nucleic acids allows detection devices with complex behaviors to be designed de novo. While highly specific, these high-order circuits are usually sequence constrained, making their adaptability toward...
17.
Sun Q, Raeeszadeh-Sarmazdeh M, Tsai S, Chen W
Methods Mol Biol
. 2022 Jun;
2487:113-131.
PMID: 35687232
Proteins are not designed to be standalone entities and must coordinate their collective action for optimum performance. Nature has developed through evolution the ability to co-localize the functional partners of...
18.
Hunt V, Chen W
Chem Commun (Camb)
. 2022 May;
58(42):6215-6218.
PMID: 35507371
To effectively reprogram cellular regulatory networks towards desired phenotypes, it is critical to have the ability to provide precise gene regulation in a spatiotemporal manner. We have previously engineered toehold-gated...
19.
Mitkas A, Valverde M, Chen W
Nat Chem Biol
. 2022 Apr;
18(5):492-500.
PMID: 35468950
In nature, dynamic interactions between enzymes play a crucial role in defining cellular metabolism. By controlling the spatial and temporal organization of these supramolecular complexes called metabolons, natural metabolism can...
20.
Lieser R, Hartzell E, Yur D, Sullivan M, Chen W
Bioconjug Chem
. 2022 Feb;
33(3):452-462.
PMID: 35167278
Naturally occurring protein nanocages are promising drug carriers because of their uniform size and biocompatibility. Engineering efforts have enhanced the delivery properties of nanocages, but cell specificity and high drug...