Wiebke Hessenkemper
Overview
Explore the profile of Wiebke Hessenkemper including associated specialties, affiliations and a list of published articles.
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12
Citations
189
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Recent Articles
1.
Bongartz H, Gille K, Hessenkemper W, Mandel K, Lewitzky M, Feller S, et al.
Cell Commun Signal
. 2019 Oct;
17(1):135.
PMID: 31651330
Background: Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signalling accounts for neoplastic, developmental, and inflammatory...
2.
Roell D, Rosler T, Hessenkemper W, Kraft F, Hauschild M, Bartsch S, et al.
J Steroid Biochem Mol Biol
. 2019 Jan;
188:59-70.
PMID: 30615932
Androgen receptor (AR) antagonists are used for hormone therapy of prostate cancer (PCa). However resistance to the treatment occurs eventually. One possible reason is the occurrence of AR mutations that...
3.
Thiele S, Heise S, Hessenkemper W, Bongartz H, Fensky M, Schaper F, et al.
IEEE/ACM Trans Comput Biol Bioinform
. 2018 Jul;
PMID: 29993657
Modern methods for the inference of cellular networks from experimental data often express nondeterminism through an ensemble of candidate models. To discriminate among these candidates new experiments need to be...
4.
Bongartz H, Hessenkemper W, Muller C, Fensky M, Fritsch J, Mandel K, et al.
Cell Signal
. 2017 Apr;
35:37-47.
PMID: 28365441
The constitutively active Janus kinase 2 mutant Jak2-V617F is responsible for cytokine-independent growth of hematopoietic cells and the development of myeloproliferative neoplasms, such as polycythaemia vera and essential thrombocythaemia. Cells...
5.
Asim M, Massie C, Orafidiya F, Pertega-Gomes N, Warren A, Esmaeili M, et al.
J Natl Cancer Inst
. 2015 Dec;
108(5).
PMID: 26657335
Background: The androgen receptor (AR) is a major drug target in prostate cancer (PCa). We profiled the AR-regulated kinome to identify clinically relevant and druggable effectors of AR signaling. Methods:...
6.
Dittrich A, Hessenkemper W, Schaper F
Cytokine Growth Factor Rev
. 2015 Jul;
26(5):595-602.
PMID: 26187858
Interleukin-6-type cytokines play important roles in the communication between cells of multicellular organisms. They are involved in the regulation of complex cellular processes such as proliferation and differentiation and act...
7.
Lorenz V, Hessenkemper W, Rodiger J, Kyrylenko S, Kraft F, Baniahmad A
Horm Mol Biol Clin Investig
. 2015 May;
7(1):265-72.
PMID: 25961265
Cellular senescence leads to an irreversible block of cellular division capacity both in cell culture and in vivo. The induction of an irreversible cell cycle arrest is very useful for...
8.
Wolf A, Eulenfeld R, Bongartz H, Hessenkemper W, Simister P, Lievens S, et al.
Cell Signal
. 2014 Dec;
27(2):340-52.
PMID: 25460044
The timely orchestration of multiple signalling pathways is crucial for the integrity of an organism and therefore tightly controlled. Gab family proteins coordinate signal transduction at the plasma membrane (PM)...
9.
Hessenkemper W, Baniahmad A
Horm Mol Biol Clin Investig
. 2014 Dec;
11(1):321-8.
PMID: 25436691
Abstract The androgen receptor (AR) plays a major role for normal prostate growth and also promotes the development and progression of prostate cancer (PCa). PCa, an important age-related disease, is...
10.
Roediger J, Hessenkemper W, Bartsch S, Manvelyan M, Huettner S, Liehr T, et al.
Mol Cancer
. 2014 Sep;
13:214.
PMID: 25216853
Background: Prostate cancer (PCa) is the second leading cause of cancer mortality of men in Western countries. The androgen receptor (AR) and AR-agonists (androgens) are required for the development and...