Whitney M Cleghorn
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Explore the profile of Whitney M Cleghorn including associated specialties, affiliations and a list of published articles.
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15
Citations
464
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Recent Articles
1.
Cleghorn W, Burrell A, Giarmarco M, Brock D, Wang Y, Chambers Z, et al.
J Biol Chem
. 2021 Nov;
298(1):101441.
PMID: 34813793
Inosine monophosphate dehydrogenase (IMPDH) is a key regulatory enzyme in the de novo synthesis of the purine base guanine. Dominant mutations in human IMPDH1 cause photoreceptor degeneration for reasons that...
2.
Tsantilas K, Cleghorn W, Bisbach C, Whitson J, Hass D, Robbings B, et al.
Invest Ophthalmol Vis Sci
. 2021 Nov;
62(14):20.
PMID: 34797906
Purpose: The purpose of this study was to present our hypothesis that aging alters metabolic function in ocular tissues. We tested the hypothesis by measuring metabolism in aged murine tissues...
3.
Giarmarco M, Brock D, Robbings B, Cleghorn W, Tsantilas K, Kuch K, et al.
Proc Natl Acad Sci U S A
. 2020 Nov;
117(46):28816-28827.
PMID: 33144507
Cone photoreceptors in the retina are exposed to intense daylight and have higher energy demands in darkness. Cones produce energy using a large cluster of mitochondria. Mitochondria are susceptible to...
4.
Bisbach C, Hutto R, Poria D, Cleghorn W, Abbas F, Vinberg F, et al.
Sci Rep
. 2020 Sep;
10(1):16041.
PMID: 32994451
Rods and cones use intracellular Ca to regulate many functions, including phototransduction and neurotransmission. The Mitochondrial Calcium Uniporter (MCU) complex is thought to be the primary pathway for Ca entry...
5.
Hutto R, Bisbach C, Abbas F, Brock D, Cleghorn W, Parker E, et al.
Cell Death Differ
. 2019 Aug;
27(3):1067-1085.
PMID: 31371786
Photoreceptors are specialized neurons that rely on Ca to regulate phototransduction and neurotransmission. Photoreceptor dysfunction and degeneration occur when intracellular Ca homeostasis is disrupted. Ca homeostasis is maintained partly by...
6.
Giarmarco M, Cleghorn W, Hurley J, Brockerhoff S
J Vis Exp
. 2018 May;
(135).
PMID: 29806828
The retina is a complex tissue that initiates and integrates the first steps of vision. Dysfunction of retinal cells is a hallmark of many blinding diseases, and future therapies hinge...
7.
Cleghorn W, Bulus N, Kook S, Gurevich V, Zent R, Gurevich E
Cell Signal
. 2017 Nov;
42:259-269.
PMID: 29133163
Arrestins recruit a variety of signaling proteins to active phosphorylated G protein-coupled receptors in the plasma membrane and to the cytoskeleton. Loss of arrestins leads to decreased cell migration, altered...
8.
Giarmarco M, Cleghorn W, Sloat S, Hurley J, Brockerhoff S
J Neurosci
. 2017 Jan;
37(8):2061-2072.
PMID: 28115482
Ca ions have distinct roles in the outer segment, cell body, and synaptic terminal of photoreceptors. We tested the hypothesis that distinct Ca domains are maintained by Ca uptake into...
9.
Du J, Rountree A, Cleghorn W, Contreras L, Lindsay K, Sadilek M, et al.
J Biol Chem
. 2015 Dec;
291(9):4698-710.
PMID: 26677218
Production of energy in a cell must keep pace with demand. Photoreceptors use ATP to maintain ion gradients in darkness, whereas in light they use it to support phototransduction. Matching...
10.
Cleghorn W, Branch K, Kook S, Arnette C, Bulus N, Zent R, et al.
Mol Biol Cell
. 2014 Dec;
26(4):622-35.
PMID: 25540425
Focal adhesions (FAs) play a key role in cell attachment, and their timely disassembly is required for cell motility. Both microtubule-dependent targeting and recruitment of clathrin are critical for FA...