Non-visual Arrestins Regulate the Focal Adhesion Formation Via Small GTPases RhoA and Rac1 Independently of GPCRs

Overview

Journal Cell Signal

Date 2017 Nov 15

PMID 29133163

Citations 11

Authors

Whitney M Cleghorn

Nada Bulus

Seunghyi Kook

Vsevolod V Gurevich

Roy Zent

Eugenia V Gurevich

Affiliations

Soon will be listed here.

Abstract

Arrestins recruit a variety of signaling proteins to active phosphorylated G protein-coupled receptors in the plasma membrane and to the cytoskeleton. Loss of arrestins leads to decreased cell migration, altered cell shape, and an increase in focal adhesions. Small GTPases of the Rho family are molecular switches that regulate actin cytoskeleton and affect a variety of dynamic cellular functions including cell migration and cell morphology. Here we show that non-visual arrestins differentially regulate RhoA and Rac1 activity to promote cell spreading via actin reorganization, and focal adhesion formation via two distinct mechanisms. Arrestins regulate these small GTPases independently of G-protein-coupled receptor activation.

Citing Articles

GPCR-dependent and -independent arrestin signaling.

Gurevich V, Gurevich E Trends Pharmacol Sci. 2024; 45(7):639-650.

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Arrestins: A Small Family of Multi-Functional Proteins.

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