Werner J H Koopman
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Explore the profile of Werner J H Koopman including associated specialties, affiliations and a list of published articles.
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126
Citations
4278
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Recent Articles
1.
Teixeira J, Benfeito S, Carreira R, Barbosa A, Amorim R, Tavares L, et al.
Biochim Biophys Acta Bioenerg
. 2025 Jan;
1866(2):149535.
PMID: 39788276
Mitochondrial dysfunction and increased reactive oxygen species (ROS) generation play an import role in different human pathologies. In this context, mitochondrial targeting of potentially protective antioxidants by their coupling to...
2.
Gan Z, van der Stelt I, Li W, Hu L, Song J, Grefte S, et al.
Antioxid Redox Signal
. 2024 Nov;
41(13-15):927-956.
PMID: 39585234
Dimeric nicotinamide nucleotide transhydrogenase (NNT) is embedded in the mitochondrial inner membrane and couples the conversion of NADP/NADH into NADPH/NAD to mitochondrial matrix proton influx. NNT was implied in various...
3.
Bergmans J, van de Westerlo E, Grefte S, Adjobo-Hermans M, Koopman W
Methods Mol Biol
. 2024 Nov;
2878():223-232.
PMID: 39546265
Mitochondrial morphology and membrane potential (Δψ) are important readouts of mitochondrial function. Integrated analysis of these parameters in living cells can be performed using fluorescent lipophilic cations, which enter cells...
4.
Wydrych A, Pakula B, Jakubek-Olszewska P, Janikiewicz J, Dobosz A, Cudna A, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Oct;
1871(1):167541.
PMID: 39419454
Mutations in the following genes: PANK2, PLA2G6, C19orf12, WDR45, CP, FA2H, ATP13A2, FTL, DCAF17, and CoASY are associated with the development of different subtypes of inherited rare disease Neurodegeneration with...
5.
van de Wal M, Doornbos C, Bibbe J, Homberg J, Van Karnebeek C, Huynen M, et al.
Biochim Biophys Acta Proteins Proteom
. 2024 Oct;
1873(1):141055.
PMID: 39395749
Paediatric Leigh syndrome (LS) is an early-onset and fatal neurodegenerative disorder lacking treatment options. LS is frequently caused by mutations in the NDUFS4 gene, encoding an accessory subunit of mitochondrial...
6.
Chen X, Tsvetkov A, Shen H, Isidoro C, Ktistakis N, Linkermann A, et al.
Autophagy
. 2024 Mar;
20(6):1213-1246.
PMID: 38442890
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to....
7.
Janssen Daalen J, Koopman W, Saris C, Meinders M, Thijssen D, Bloem B
Mov Disord
. 2023 Dec;
39(2):273-293.
PMID: 38140810
Parkinson's disease (PD) is a progressive neurodegenerative disorder for which only symptomatic treatments are available. Both preclinical and clinical studies suggest that moderate hypoxia induces evolutionarily conserved adaptive mechanisms that...
8.
Desai S, Grefte S, van de Westerlo E, Lauwen S, Paters A, Prehn J, et al.
Biochim Biophys Acta Bioenerg
. 2023 Dec;
1865(2):149027.
PMID: 38109971
Mitochondrial membrane potential (Δψ) and morphology are considered key readouts of mitochondrial functional state. This morphofunction can be studied using fluorescent dyes ("probes") like tetramethylrhodamine methyl ester (TMRM) and Mitotrackers...
9.
SMDT1 variants impair EMRE-mediated mitochondrial calcium uptake in patients with muscle involvement
Bulthuis E, Adjobo-Hermans M, de Potter B, Hoogstraten S, Wezendonk L, Tutakhel O, et al.
Biochim Biophys Acta Mol Basis Dis
. 2023 Jul;
1869(8):166808.
PMID: 37454773
Ionic calcium (Ca) is a key messenger in signal transduction and its mitochondrial uptake plays an important role in cell physiology. This uptake is mediated by the mitochondrial Ca uniporter...
10.
Ferreira A, Kostidis S, Groh L, Koeken V, Bruno M, Baydemir I, et al.
Cell Rep
. 2023 Jun;
42(6):112658.
PMID: 37330914
Itaconate is an immunomodulatory metabolite produced by immune cells under microbial stimulation and certain pro-inflammatory conditions and triggers antioxidant and anti-inflammatory responses. We show that dimethyl itaconate, a derivative of...