Wenzel M Hackeng
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Explore the profile of Wenzel M Hackeng including associated specialties, affiliations and a list of published articles.
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26
Citations
406
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Recent Articles
1.
Hackeng W, Dreijerink K, Brosens L
J Pathol
. 2025 Feb;
PMID: 40007046
Predicting metachronous metastases in localized pancreatic neuroendocrine tumors (PanNETs) and improving survival of patients with advanced disease are some of the most important goals in PanNET research. Both are addressed...
2.
van T Veld B, Hackeng W, Luchini C, Brosens L, Dreijerink K
Endocr Pathol
. 2025 Feb;
36(1):3.
PMID: 39954168
Functioning pancreatic neuroendocrine tumors (PanNETs) represent a subset of PanNETs that cause symptoms due to hormonal activity. Insulinoma is the most common functioning PanNET type. Mutations in the alpha thalassemia/mental...
3.
Mattiolo P, Bevere M, Mafficini A, Verschuur A, Calicchia M, Hackeng W, et al.
Endocr Pathol
. 2024 Sep;
35(4):354-361.
PMID: 39331358
Glucagonomas are functioning pancreatic neuroendocrine tumors (PanNETs) responsible for glucagonoma syndrome. This study aims to shed light on the clinicopathological and molecular features of these neoplasms. Six patients with glucagonomas...
4.
Verschuur A, Hackeng W, Westerbeke F, Benhamida J, Basturk O, Selenica P, et al.
Clin Gastroenterol Hepatol
. 2024 Feb;
22(6):1245-1254.e10.
PMID: 38382726
Background & Aims: Cytologic and histopathologic diagnosis of non-ductal pancreatic neoplasms can be challenging in daily clinical practice, whereas it is crucial for therapy and prognosis. The cancer methylome is...
5.
Dayton T, Alcala N, Moonen L, den Hartigh L, Geurts V, Mangiante L, et al.
Cancer Cell
. 2023 Dec;
41(12):2083-2099.e9.
PMID: 38086335
Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for patients with NENs are limited, in part due to lack of accurate models....
6.
Verschuur A, Kok A, Morsink F, de Leng W, van den Broek M, Koudijs M, et al.
Am J Surg Pathol
. 2023 May;
47(7):785-791.
PMID: 37199453
A clinical diagnosis of multiple endocrine neoplasia type 1 (MEN1) syndrome is usually confirmed with genetic testing in the germline. It is expected that menin protein expression is lost in...
7.
Hackeng W, Brosens L, Dreijerink K
Endocr Relat Cancer
. 2023 Feb;
30(5).
PMID: 36779771
Insulinomas are rare functional pancreatic neuroendocrine tumors. While most insulinomas are indolent and cured after surgery, 10-15% of cases show aggressive or malignant tumor behavior and metastasize locally or to...
8.
Hackeng W, Assi H, Westerbeke F, Brosens L, Heaphy C
Surg Pathol Clin
. 2022 Sep;
15(3):541-554.
PMID: 36049835
Pancreatic neuroendocrine tumors (PanNETs) represent a clinically challenging disease because these tumors vary in clinical presentation, natural history, and prognosis. Novel prognostic biomarkers are needed to improve patient stratification and...
9.
Yachida S, Totoki Y, Noe M, Nakatani Y, Horie M, Kawasaki K, et al.
Cancer Discov
. 2021 Dec;
12(3):692-711.
PMID: 34880079
Significance: GIS-NECs are genetically distinct from GIS-NETs. GIS-NECs arising in different organs show similar histopathologic features and share some genomic features, but considerable differences exist between Panc-NECs and Nonpanc-NECs. In...
10.
Dreijerink K, Hackeng W, Singhi A, Heaphy C, Brosens L
J Pathol
. 2021 Nov;
256(2):143-148.
PMID: 34750813
Primary non-functional pancreatic neuroendocrine tumors (NF-PanNETs) are a heterogeneous group of neuroendocrine neoplasms that display highly variable clinical behavior. Therefore, NF-PanNETs often present clinical teams with a dilemma: the uncertain...