Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System

Overview

Journal Cancer Discov

Specialty Oncology

Date 2021 Dec 9

PMID 34880079

Citations 47

Authors

Shinichi Yachida

Yasushi Totoki

Michael Noe

Yoichiro Nakatani

Masafumi Horie

Kenta Kawasaki

Hiromi Nakamura

Mihoko Saito-Adachi

Masami Suzuki

Erina Takai

Natsuko Hama

Ryota Higuchi

Seiko Hirono

Satoshi Shiba

Mamoru Kato

Eisaku Furukawa

Yasuhito Arai

Hirofumi Rokutan

Taiki Hashimoto

Shuichi Mitsunaga

Mitsuro Kanda

Hidenori Tanaka

So Takata

Ayaka Shimomura

Minoru Oshima

Wenzel M Hackeng

Tomoyuki Okumura

Keiichi Okano

Masakazu Yamamoto

Hiroki Yamaue

Chigusa Morizane

Koji Arihiro

Toru Furukawa

Toshiro Sato

Tohru Kiyono

Lodewijk A A Brosens

Laura D Wood

Ralph H Hruban

Tatsuhiro Shibata

Affiliations

Soon will be listed here.

Abstract

Significance: GIS-NECs are genetically distinct from GIS-NETs. GIS-NECs arising in different organs show similar histopathologic features and share some genomic features, but considerable differences exist between Panc-NECs and Nonpanc-NECs. In addition, Panc-NECs could be classified into two subgroups (i.e., "ductal-type" and "acinar-type") based on genomic and epigenomic features. This article is highlighted in the In This Issue feature, p. 587.

Citing Articles

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Comprehensive molecular portrait reveals genetic diversity and distinct molecular subtypes of small intestinal neuroendocrine tumors.

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