Weng Hua Khoo
Overview
Explore the profile of Weng Hua Khoo including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
689
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Recent Articles
1.
Kyaw W, Chai R, Khoo W, Goldstein L, Croucher P, Murray J, et al.
Bioinformatics
. 2023 Dec;
39(12).
PMID: 38113422
Motivation: Cell fate is commonly studied by profiling the gene expression of single cells to infer developmental trajectories based on expression similarity, RNA velocity, or statistical mechanical properties. However, current...
2.
Bhattacharyya N, Kyaw W, McDonald M, Dhenni R, Grootveld A, Xiao Y, et al.
Nat Protoc
. 2023 Oct;
18(12):3856-3880.
PMID: 37857852
Intravital two-photon microscopy enables deep-tissue imaging at high temporospatial resolution in live animals. However, the endosteal bone compartment and underlying bone marrow pose unique challenges to optical imaging as light...
3.
Grootveld A, Kyaw W, Panova V, Lau A, Ashwin E, Seuzaret G, et al.
Cell
. 2023 Mar;
186(6):1144-1161.e18.
PMID: 36868219
Germinal centers (GCs) that form within lymphoid follicles during antibody responses are sites of massive cell death. Tingible body macrophages (TBMs) are tasked with apoptotic cell clearance to prevent secondary...
4.
Phetsouphanh C, Khoo W, Jackson K, Klemm V, Howe A, Aggarwal A, et al.
Front Immunol
. 2022 Dec;
13:1032911.
PMID: 36544780
Background: Long-term immunity to SARS-CoV-2 infection, including neutralizing antibodies and T cell-mediated immunity, is required in a very large majority of the population in order to reduce ongoing disease burden....
5.
Khoo W, Jackson K, Phetsouphanh C, Zaunders J, Alquicira-Hernandez J, Yazar S, et al.
Clin Immunol
. 2022 Dec;
246:109209.
PMID: 36539107
Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop less severe coronavirus disease 2019 (COVID-19) than adults. The mechanisms for the age-specific differences and the implications for infection-induced...
6.
Ren Q, Khoo W, Corr A, Phan T, Croucher P, Stewart S
Breast Cancer Res
. 2022 Jan;
24(1):10.
PMID: 35093137
Background: Breast cancer can recur months to decades after an initial diagnosis and treatment. The mechanisms that control tumor cell dormancy remain poorly understood, making it difficult to predict which...
7.
McDonald M, Khoo W, Ng P, Xiao Y, Zamerli J, Thatcher P, et al.
Cell
. 2021 Apr;
184(7):1940.
PMID: 33798441
No abstract available.
8.
McDonald M, Khoo W, Ng P, Xiao Y, Zamerli J, Thatcher P, et al.
Cell
. 2021 Feb;
184(5):1330-1347.e13.
PMID: 33636130
Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage-derived precursors that are thought to undergo apoptosis once resorption is complete. Here, by intravital imaging, we reveal that...
9.
Owen K, Gearing L, Zanker D, Brockwell N, Khoo W, Roden D, et al.
EMBO Rep
. 2020 Apr;
21(6):e50162.
PMID: 32314873
The latency associated with bone metastasis emergence in castrate-resistant prostate cancer is attributed to dormancy, a state in which cancer cells persist prior to overt lesion formation. Using single-cell transcriptomics...
10.
Khoo W, Ledergor G, Weiner A, Roden D, Terry R, McDonald M, et al.
Blood
. 2019 Apr;
134(1):30-43.
PMID: 31023703
The era of targeted therapies has seen significant improvements in depth of response, progression-free survival, and overall survival for patients with multiple myeloma. Despite these improvements in clinical outcome, patients...