Wendy N Jefferson
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Explore the profile of Wendy N Jefferson including associated specialties, affiliations and a list of published articles.
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55
Citations
1940
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Recent Articles
1.
McWilliams M, Koohestani F, Jefferson W, Gunewardena S, Shivashankar K, Wertenberger R, et al.
bioRxiv
. 2024 Sep;
PMID: 39314474
Uterine fibroids (leiomyomas), benign tumors of the myometrial smooth muscle layer, are present in over 75% of women, often causing severe pain, menorrhagia and reproductive dysfunction. The molecular pathogenesis of...
2.
Jefferson W, Wang T, Padilla-Banks E, Williams C
Nucleic Acids Res
. 2024 Aug;
52(18):10897-10917.
PMID: 39166489
Chromatin changes in response to estrogen and progesterone are well established in cultured cells, but how they control gene expression under physiological conditions is largely unknown. To address this question,...
3.
Padilla-Banks E, Jefferson W, Papas B, Suen A, Xu X, Carreon D, et al.
PLoS Biol
. 2023 Oct;
21(10):e3002334.
PMID: 37856394
Tissue development entails genetically programmed differentiation of immature cell types to mature, fully differentiated cells. Exposure during development to non-mutagenic environmental factors can contribute to cancer risk, but the underlying...
4.
Jefferson T, Wang T, Jefferson W, Li Y, Hamilton K, Wade P, et al.
Epigenetics
. 2022 Nov;
18(1):2139986.
PMID: 36328762
Clinically, developmental exposure to the endocrine disrupting chemical, diethylstilboestrol (DES), results in long-term male and female infertility. Experimentally, developmental exposure to DES results in abnormal reproductive tract phenotypes in male...
5.
Jefferson W, Padilla-Banks E, Suen A, Royer L, Zeldin S, Arora R, et al.
Environ Health Perspect
. 2020 Mar;
128(3):37001.
PMID: 32186404
Background: Embryo implantation relies on precise hormonal regulation, associated gene expression changes, and appropriate female reproductive tract tissue architecture. Female mice exposed neonatally to the phytoestrogen genistein (GEN) at doses...
6.
Herrera G, Lierz S, Harris E, Donoghue L, Hewitt S, Rodriguez K, et al.
Endocrinology
. 2019 Dec;
161(2).
PMID: 31883000
Estrogen receptor α (ESR1; encoded by Esr1) is a crucial nuclear transcription factor for female reproduction and is expressed throughout the female reproductive tract. To assess the function of ESR1...
7.
Belcher S, Cline J, Conley J, Groeters S, Jefferson W, Law M, et al.
Toxicol Pathol
. 2019 Dec;
47(8):1049-1071.
PMID: 31833458
During the past 20 years, investigations involving endocrine active substances (EAS) and reproductive toxicity have dominated the landscape of ecotoxicological research. This has occurred in concert with heightened awareness in...
8.
Suen A, Jefferson W, Wood C, Williams C
Mol Cancer Res
. 2019 Oct;
17(12):2369-2382.
PMID: 31597742
Early-life exposure to estrogenic chemicals can increase cancer risk, likely by disrupting normal patterns of cellular differentiation. Female mice exposed neonatally to the synthetic estrogen diethylstilbestrol (DES) develop metaplastic and...
9.
Nanjappa M, Mesa A, Medrano T, Jefferson W, DeMayo F, Williams C, et al.
Biol Reprod
. 2019 Jun;
101(2):306-317.
PMID: 31201420
Enhancer of zeste homolog 2 (EZH2) is a rate-limiting catalytic subunit of a histone methyltransferase, polycomb repressive complex, which silences gene activity through the repressive histone mark H3K27me3. EZH2 is...
10.
Suen A, Jefferson W, Williams C, Wood C
Toxicol Pathol
. 2018 Jun;
46(5):574-596.
PMID: 29895210
Developmental exposure to estrogenic chemicals is an established risk factor for cancer of the female reproductive tract. This increase in risk has been associated with disruption of normal patterns of...