Wen-Hwa Lee
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Explore the profile of Wen-Hwa Lee including associated specialties, affiliations and a list of published articles.
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89
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3217
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Recent Articles
1.
Tien S, Chang C, Huang C, Peng H, Chang Y, Chang M, et al.
iScience
. 2024 Jul;
27(7):110346.
PMID: 39055920
Over 80% of the patients with pancreatic ductal adenocarcinoma (PDAC) have cachexia/wasting syndrome. Cachexia is associated with reduced survival, decreased quality of life, and higher metastasis rates. Here, we demonstrate...
2.
Lai T, Chiang T, Lee C, Kuo T, Wu C, Chen Y, et al.
Br J Cancer
. 2024 Feb;
130(7):1096-1108.
PMID: 38341509
Background: Pancreatic neuroendocrine tumors (PNETs) with low microvessel density and fibrosis often exhibit clinical aggressiveness. Given the contribution of cancer-associated fibroblasts (CAFs) to the hypovascular fibrotic stroma in pancreatic ductal...
3.
Oncogenic KRAS, Mucin 4, and Activin A-Mediated Fibroblast Activation Cooperate for PanIN Initiation
Hu C, Huang C, Hsu M, Chien H, Wu P, Chen Y, et al.
Adv Sci (Weinh)
. 2023 Nov;
10(36):e2301240.
PMID: 37964407
Over 90% of patients with pancreatic ductal adenocarcinoma (PDAC) have oncogenic KRAS mutations. Nevertheless, mutated KRAS alone is insufficient to initiate pancreatic intraepithelial neoplasia (PanIN), the precursor of PDAC. The...
4.
Lee W, Chen X, Liu I, Lee J, Hu C, Wu H, et al.
Cell Rep
. 2022 Oct;
41(4):111555.
PMID: 36288706
Upregulation of interleukin-17 receptor B (IL-17RB) is known to be oncogenic, while other IL-17 receptors and ligands are generally involved in pro-inflammatory pathways. We identify a mouse neutralizing monoclonal antibody...
5.
Liu Y, Hu C, Hsu Y, Lee W
Cell Death Dis
. 2022 Sep;
13(9):817.
PMID: 36151074
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and deadliest cancer worldwide. The primary reasons for this are the lack of early detection methods and targeted therapy. Emerging...
6.
Chen Y, Chang C, Hsu M, Jeng Y, Tien Y, Chang M, et al.
Nat Commun
. 2022 May;
13(1):2945.
PMID: 35618735
Tumor cells with diverse phenotypes and biological behaviors are influenced by stromal cells through secretory factors or direct cell-cell contact. Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia with...
7.
Hsu Y, Wu P, Jeng Y, Hu C, Lee W
Am J Cancer Res
. 2022 May;
12(4):1556-1576.
PMID: 35530290
Aberrant sugar metabolism is linked to an increased risk of pancreatic cancer. Previously, we found that high glucose induces genome instability and oncogenic mutation preferentially in pancreatic cells through dysregulation...
8.
Wu H, Tsai L, Huang C, Hsu P, Chen M, Chen Y, et al.
Sci Transl Med
. 2021 Mar;
13(583).
PMID: 33658352
The members of the interleukin-17 (IL-17) cytokine family and their receptors were identified decades ago. Unlike IL-17 receptor A (IL-17RA), which heterodimerizes with IL-17RB, IL-17RC, and IL-17RD and mediates proinflammatory...
9.
Su F, Huang S, Wei P, Hsu P, Li J, Su L, et al.
Free Radic Biol Med
. 2021 Jan;
165:368-384.
PMID: 33460768
Emerging evidences implicate the contribution of ROS to T cell activation and signaling. The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation....
10.
Hsu J, Chou J, Chen T, Hsu J, Su F, Lan J, et al.
EMBO Mol Med
. 2019 Nov;
12(1):e9386.
PMID: 31782617
Human caspase-4 and its mouse homolog caspase-11 are receptors for cytoplasmic lipopolysaccharide. Activation of the caspase-4/11-dependent NLRP3 inflammasome is required for innate defense and endotoxic shock, but how caspase-4/11 is...