Wen-Chih Lee
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Explore the profile of Wen-Chih Lee including associated specialties, affiliations and a list of published articles.
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36
Citations
1148
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Recent Articles
1.
Tsai Y, Tseng Y, Wu Y, Song W, You M, Hsu Y, et al.
Nat Commun
. 2025 Jan;
16(1):896.
PMID: 39837836
Adult human hearts exhibit limited regenerative capacity. Post-injury cardiomyocyte (CM) loss can lead to myocardial dysfunction and failure. Although neonatal mammalian hearts can regenerate, the underlying molecular mechanisms remain elusive....
2.
Lai C, Lin G, Lee W, Chang C
MethodsX
. 2024 Oct;
13:102982.
PMID: 39430779
Aphids, as hemipteran insects, reproduce via parthenogenesis and viviparity, resulting in rapid and exponential offspring production. To investigate the molecular mechanisms underlying parthenogenetic viviparity in asexual aphids, precise protein detection...
3.
Ji X, Seeley R, Li K, Song F, Liao X, Song C, et al.
Cell Chem Biol
. 2023 Aug;
30(9):1053-1063.e5.
PMID: 37562406
Type I diabetes (T1D) impairs bone accrual in patients, but the mechanism is unclear. Here in a murine monogenic model for T1D, we demonstrate that diabetes suppresses bone formation resulting...
4.
Lin W, Dharini K, Peng C, Lin C, Yeh K, Lee W, et al.
Tzu Chi Med J
. 2022 Dec;
34(4):373-380.
PMID: 36578638
Glucocorticoid-induced osteoporosis (GIOP) is the most common form of secondary osteoporosis due to excessive or long-term glucocorticoid administration, disturbing the homeostasis between bone formation and bone resorption. The bone biology...
5.
Lin G, Chung C, Cook C, Lin M, Lee W, Chang C
Dev Genes Evol
. 2022 Jun;
232(2-4):51-65.
PMID: 35678925
Aphids are hemimetabolous insects that undergo incomplete metamorphosis without pupation. The annual life cycle of most aphids includes both an asexual (viviparous) and a sexual (oviparous) phase. Sexual reproduction only...
6.
Li K, Ji X, Seeley R, Lee W, Shi Y, Song F, et al.
FASEB J
. 2022 May;
36(6):e22377.
PMID: 35608871
Osteoarthritis (OA) is the leading joint disease characterized by cartilage destruction and loss of mobility. Accumulating evidence indicates that the incidence and severity of OA increases with diabetes, implicating systemic...
7.
Wang T, Tseng W, Leu Y, Chen C, Lee W, Chi Y, et al.
Nat Commun
. 2022 Mar;
13(1):1238.
PMID: 35264584
In the long history of traditional Chinese medicine, single herbs and complex formulas have been suggested to increase lifespan. However, the identification of single molecules responsible for lifespan extension has...
8.
Su X, Xu Y, Fox G, Xiang J, Kwakwa K, Davis J, et al.
J Clin Invest
. 2021 Sep;
131(20).
PMID: 34520398
Tumor-infiltrating myeloid cells contribute to the development of the immunosuppressive tumor microenvironment. Myeloid cell expression of arginase 1 (ARG1) promotes a protumor phenotype by inhibiting T cell function and depleting...
9.
Tseng W, Chen C, Chern C, Wang C, Lee W, Chi Y, et al.
Int J Mol Sci
. 2021 Apr;
22(9).
PMID: 33922657
BRCA mutation, one of the most common types of mutations in breast and ovarian cancer, has been suggested to be synthetically lethal with depletion of RAD52. Pharmacologically inhibiting RAD52 specifically...
10.
Lee W, Ji X, Nissim I, Long F
Cell Rep
. 2020 Sep;
32(10):108108.
PMID: 32905773
The metabolic program of osteoblasts, the chief bone-making cells, remains incompletely understood. Here in murine calvarial cells, we establish that osteoblast differentiation under aerobic conditions is coupled with a marked...