Wen-Chieh Pi
Overview
Explore the profile of Wen-Chieh Pi including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
249
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0
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Recent Articles
1.
Cheng I, Pi W, Hsu C, Guo Y, Lai J, Wang G, et al.
Cell Death Discov
. 2024 May;
10(1):244.
PMID: 38773077
TFIID, one of the general transcription factor (GTF), regulates transcriptional initiation of protein-coding genes through direct binding to promoter elements and subsequent recruitment of other GTFs and RNA polymerase II....
2.
Liao C, Wang Y, Pi W, Wang C, Wu Y, Chen W, et al.
Nat Commun
. 2023 Sep;
14(1):5518.
PMID: 37684250
The transcription factor TATA-box binding protein (TBP) modulates gene expression in nuclei. This process requires the involvement of nuclear transport receptors, collectively termed karyopherin-β (Kap-β) in yeast, and various regulatory...
3.
Ren Z, Kim A, Huang Y, Pi W, Gong W, Yu X, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(9).
PMID: 35217626
Acute myeloid leukemias (AMLs) with the NUP98-NSD1 or mixed lineage leukemia (MLL) rearrangement (MLL-r) share transcriptomic profiles associated with stemness-related gene signatures and display poor prognosis. The molecular underpinnings of...
4.
Wang J, Yu X, Gong W, Liu X, Park K, Ma A, et al.
Nat Cell Biol
. 2022 Feb;
24(3):384-399.
PMID: 35210568
Canonically, EZH2 serves as the catalytic subunit of PRC2, which mediates H3K27me3 deposition and transcriptional repression. Here, we report that in acute leukaemias, EZH2 has additional noncanonical functions by binding...
5.
Lee Y, Ito K, Pi W, Lin I, Chu C, Malik S, et al.
Proc Natl Acad Sci U S A
. 2021 Feb;
118(6).
PMID: 33542097
The chimeric transcription factor E2A-PBX1, containing the N-terminal activation domains of E2A fused to the C-terminal DNA-binding domain of PBX1, results in 5% of pediatric acute lymphoblastic leukemias (ALL). We...
6.
Fan H, Lu J, Guo Y, Li D, Zhang Z, Tsai Y, et al.
Nat Genet
. 2020 Nov;
52(12):1384-1396.
PMID: 33139953
Trimethylated histone H3 lysine 27 (H3K27me3) regulates gene repression, cell-fate determination and differentiation. We report that a conserved bromo-adjacent homology (BAH) module of BAHCC1 (BAHCC1) 'recognizes' H3K27me3 specifically and enforces...
7.
Shi T, Huang Y, Chen C, Pi W, Hsu Y, Lo L, et al.
Biochem Biophys Res Commun
. 2020 Sep;
533(3):467-473.
PMID: 32977949
The coronavirus disease 2019 (COVID-19) pandemic caused by 2019 novel coronavirus (2019-nCoV) has been a crisis of global health, whereas the effective vaccines against 2019-nCoV are still under development. Alternatively,...
8.
Karyopherin Kap114p-mediated trans-repression controls ribosomal gene expression under saline stress
Liao C, Shankar S, Pi W, Chang C, Ahmed G, Chen W, et al.
EMBO Rep
. 2020 Jun;
21(7):e48324.
PMID: 32484313
Nuclear accessibility of transcription factors controls gene expression, co-regulated by Ran-dependent nuclear localization and a competitive regulatory network. Here, we reveal that nuclear import factor-facilitated transcriptional repression attenuates ribosome biogenesis...
9.
Pi W, Wang J, Shimada M, Lin J, Geng H, Lee Y, et al.
Blood
. 2020 Apr;
136(1):11-23.
PMID: 32276273
E2A, a basic helix-loop-helix transcription factor, plays a crucial role in determining tissue-specific cell fate, including differentiation of B-cell lineages. In 5% of childhood acute lymphoblastic leukemia (ALL), the t(1,19)...
10.
Wang T, Chen C, Hsiao Y, Lin Y, Pi W, Huang P, et al.
Cancers (Basel)
. 2019 Mar;
11(3).
PMID: 30857208
The A/B subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs A/B), which includes hnRNP A1, A2/B1, and A3, plays an important role in cell proliferation. The simultaneous suppression of hnRNP A1/A2, but...