Xufen Yu
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Explore the profile of Xufen Yu including associated specialties, affiliations and a list of published articles.
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45
Citations
734
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Recent Articles
1.
Lin Y, Liu J, Tian X, Wang J, Su H, Xiang J, et al.
Eur J Med Chem
. 2025 Mar;
289:117420.
PMID: 40037061
Bruton's tyrosine kinase (BTK) has been an attractive target in the B-cell malignancies. Significant progress has been achieved in developing effective BTK-targeting small-molecule inhibitors and proteolysis targeting chimeras (PROTACs). Based...
2.
Corbin J, Yu X, Jin J, Cai L, Wang G
Oncogene
. 2024 Aug;
43(36):2722-2736.
PMID: 39112519
Breast cancer (BC) remains the second leading cause of cancer-related mortalities in women. Resistance to hormone therapies such as tamoxifen, an estrogen receptor (ER) inhibitor, is a major hurdle in...
3.
Liu J, Hu X, Luo K, Xiong Y, Chen L, Wang Z, et al.
J Am Chem Soc
. 2024 Apr;
PMID: 38597345
Deubiquitinase-targeting chimeras (DUBTACs) have been recently developed to stabilize proteins of interest, which is in contrast to targeted protein degradation (TPD) approaches that degrade disease-causing proteins. However, to date, only...
4.
Muneer A, Xie L, Xie X, Zhang F, Wrobel J, Xiong Y, et al.
bioRxiv
. 2024 Mar;
PMID: 38496599
By largely unknown mechanism(s), SARS-CoV-2 hijacks the host translation apparatus to promote COVID-19 pathogenesis. We report that the histone methyltransferase G9a noncanonically regulates viral hijacking of the translation machinery to...
5.
Velez J, Dale B, Park K, Umit Kaniskan H, Yu X, Jin J
Eur J Med Chem
. 2024 Jan;
267:116154.
PMID: 38295690
Aberrant expression of EZH2, the main catalytic subunit of PRC2, has been implicated in numerous cancers, including leukemia, breast, and prostate. Recent studies have highlighted non-catalytic oncogenic functions of EZH2,...
6.
Yu X, Li D, Kottur J, Kim H, Herring L, Yu Y, et al.
J Med Chem
. 2023 Nov;
66(23):16168-16186.
PMID: 38019706
As a core chromatin-regulatory scaffolding protein, WDR5 mediates numerous protein-protein interactions (PPIs) with other partner oncoproteins. However, small-molecule inhibitors that block these PPIs exert limited cell-killing effects. Here, we report...
7.
Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, et al.
Cell Chem Biol
. 2023 Oct;
30(12):1525-1541.e7.
PMID: 37858336
We report a novel translation-regulatory function of G9a, a histone methyltransferase and well-understood transcriptional repressor, in promoting hyperinflammation and lymphopenia; two hallmarks of endotoxin tolerance (ET)-associated chronic inflammatory complications. Using...
8.
Umana J, Wasserman S, Song L, Goel A, Yu X, Jin J, et al.
Hum Gene Ther
. 2023 Aug;
34(17-18):947-957.
PMID: 37624737
Adeno-associated virus (AAV) is a powerful gene therapy vector that has been used in several FDA-approved therapies as well as in multiple clinical trials. This vector has high therapeutic versatility...
9.
Rialdi A, Duffy M, Scopton A, Fonseca F, Zhao J, Schwarz M, et al.
Nat Cancer
. 2023 Aug;
4(8):1157-1175.
PMID: 37537299
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. β-Catenin (CTNNB1)-mutated HCC represents 30% of cases of the disease with no precision therapeutics available. Using chemical libraries derived...
10.
Schwalm M, Kramer A, Dolle A, Weckesser J, Yu X, Jin J, et al.
Cell Chem Biol
. 2023 Jun;
30(7):753-765.e8.
PMID: 37354907
The multi-step degradation process of PROteolysis TArgeting Chimeras (PROTACs) poses a challenge for their rational development, as the rate-limiting steps that determine PROTACs efficiency remain largely unknown. Moreover, the slow...