Weifan Zheng
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Explore the profile of Weifan Zheng including associated specialties, affiliations and a list of published articles.
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34
Citations
231
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Recent Articles
1.
Hei C, Li X, Wang R, Peng J, Liu P, Dong X, et al.
Sci Rep
. 2025 Feb;
15(1):7035.
PMID: 40016488
The relationship between ischemic stroke (IS) and pyroptosis centers on the inflammatory response elicited by cerebral tissue damage during an ischemic stroke event. However, an in-depth mechanistic understanding of their...
2.
Lamson D, Tarpley M, Addo K, Ji X, Abu Rabe D, Ehe B, et al.
Biochim Biophys Acta Gen Subj
. 2024 Aug;
1868(11):130692.
PMID: 39151833
Sonic hedgehog (Shh) is a morphogen with important roles in embryonic development and in the development of a number of cancers. Its activity is modulated by interactions with binding partners...
3.
Abu Rabe D, Chdid L, Lamson D, Laudeman C, Tarpley M, Elsayed N, et al.
Molecules
. 2024 Jul;
29(13.
PMID: 38999049
Aberrant activation of hedgehog (Hh) signaling has been implicated in various cancers. Current FDA-approved inhibitors target the seven-transmembrane receptor Smoothened, but resistance to these drugs has been observed. It has...
4.
Wu M, Song G, Li J, Song Z, Zhao B, Liang L, et al.
Cell
. 2024 May;
187(12):2935-2951.e19.
PMID: 38772371
Peripheral sensory neurons widely innervate various tissues to continuously monitor and respond to environmental stimuli. Whether peripheral sensory neurons innervate the spleen and modulate splenic immune response remains poorly defined....
5.
Ji X, Williams K, Zheng W
Cancer Inform
. 2023 Oct;
22:11769351231202588.
PMID: 37846218
The aim of this study was to utilize a computational methodology based on Gene Reversal Rate (GRR) scoring to repurpose existing drugs for a rare and understudied cancer: inflammatory breast...
6.
Xu Z, Eichler B, Klausner E, Duffy-Matzner J, Zheng W
Molecules
. 2022 Dec;
27(23).
PMID: 36500375
Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant...
7.
Dong X, Zheng W
Molecules
. 2022 Oct;
27(19).
PMID: 36234948
In designing effective siRNAs for a specific mRNA target, it is critically important to have predictive models for the potency of siRNAs. None of the published methods characterized the chemical...
8.
Khashan R, Tropsha A, Zheng W
Mol Inform
. 2022 Feb;
41(8):e2100248.
PMID: 35142086
Accurate prediction of binding poses is crucial to structure-based drug design. We employ two powerful artificial intelligence (AI) approaches, data-mining and machine-learning, to design artificial neural network (ANN) based pose-scoring...
9.
Moon C, Jin C, Dong X, Abrar S, Zheng W, Chirkova R, et al.
J Biomed Inform
. 2021 Jun;
119:103838.
PMID: 34119691
We aimed to develop and validate a new graph embedding algorithm for embedding drug-disease-target networks to generate novel drug repurposing hypotheses. Our model denotes drugs, diseases and targets as subjects,...
10.
Cox S, Dong X, Rai R, Christopherson L, Zheng W, Tropsha A, et al.
J Biomed Inform
. 2020 Oct;
111:103579.
PMID: 33007449
Biomedical literature contains unstructured, rich information regarding proteins, ligands, diseases as well as biological pathways in which they are involved. Systematically analyzing such textual corpus has the potential for biomedical...