Kevin P Williams
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Explore the profile of Kevin P Williams including associated specialties, affiliations and a list of published articles.
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41
Citations
539
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Recent Articles
1.
Poje G, Sakic D, Marinovic M, You J, Tarpley M, Williams K, et al.
Acta Pharm
. 2024 Nov;
74(4):595-612.
PMID: 39560310
The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid...
2.
Lamson D, Tarpley M, Addo K, Ji X, Abu Rabe D, Ehe B, et al.
Biochim Biophys Acta Gen Subj
. 2024 Aug;
1868(11):130692.
PMID: 39151833
Sonic hedgehog (Shh) is a morphogen with important roles in embryonic development and in the development of a number of cancers. Its activity is modulated by interactions with binding partners...
3.
Abu Rabe D, Chdid L, Lamson D, Laudeman C, Tarpley M, Elsayed N, et al.
Molecules
. 2024 Jul;
29(13.
PMID: 38999049
Aberrant activation of hedgehog (Hh) signaling has been implicated in various cancers. Current FDA-approved inhibitors target the seven-transmembrane receptor Smoothened, but resistance to these drugs has been observed. It has...
4.
Ji X, Williams K, Zheng W
Cancer Inform
. 2023 Oct;
22:11769351231202588.
PMID: 37846218
The aim of this study was to utilize a computational methodology based on Gene Reversal Rate (GRR) scoring to repurpose existing drugs for a rare and understudied cancer: inflammatory breast...
5.
Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia
Paiboonrungruang C, Xiong Z, Lamson D, Li Y, Bowman B, Chembo J, et al.
Redox Biol
. 2023 Sep;
67:102901.
PMID: 37776708
Objective: NRF2 is a master transcription factor that regulates the stress response. NRF2 is frequently mutated and activated in human esophageal squamous cell carcinoma (ESCC), which drives resistance to chemotherapy...
6.
Olsson L, Walens A, Hamilton A, Benefield H, Fleming J, Carey L, et al.
Cancer Epidemiol Biomarkers Prev
. 2022 Aug;
31(10):1944-1951.
PMID: 35973227
Background: Obese women have higher risk of aggressive breast tumors and distant metastasis. However, obesity has rarely been assessed in association with metastasis in diverse populations. Methods: In the Carolina...
7.
Al Abo M, Gearhart-Serna L, Van Laere S, Freedman J, Patierno S, Hwang E, et al.
NPJ Breast Cancer
. 2022 Jun;
8(1):73.
PMID: 35697736
Aggressive breast cancer variants, like triple negative and inflammatory breast cancer, contribute to disparities in survival and clinical outcomes among African American (AA) patients compared to White (W) patients. We...
8.
Jones G, Hoadley K, Benefield H, Olsson L, Hamilton A, Bhattacharya A, et al.
Breast Cancer Res Treat
. 2022 Jan;
192(2):447-455.
PMID: 35034243
Purpose: Black women have a 40% increased risk of breast cancer-related mortality. These outcome disparities may reflect differences in tumor pathways and a lack of targetable therapies for specific subtypes...
9.
Burton D, Boa-Amponsem O, Dixon M, Hopkins M, Herbin T, Toney S, et al.
J Neurosci Res
. 2022 Jan;
100(8):1585-1601.
PMID: 35014067
Ethanol exposure during the early stages of embryonic development can lead to a range of morphological and behavioral differences termed fetal alcohol spectrum disorders (FASDs). In a zebrafish model, we...
10.
Lamson D, Hughes M, Adcock A, Smith G, Williams K
MethodsX
. 2021 Aug;
8:101207.
PMID: 34434730
Sonic hedgehog (Shh) is a morphogenic protein with critical roles in embryogenesis and the development of some cancers. Hence, identifying inhibitors of the Shh pathway is of great therapeutic value....