Vignesh Kasinath
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Explore the profile of Vignesh Kasinath including associated specialties, affiliations and a list of published articles.
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20
Citations
660
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Recent Articles
1.
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol
. 2025 Jan;
32(2):393-404.
PMID: 39774834
Polycomb repressive complex 2 (PRC2) trimethylates histone H3 on K27 (H3K27me3) leading to gene silencing that is essential for embryonic development and maintenance of cell identity. PRC2 is regulated by...
2.
Song J, Yao L, Gooding A, Thron V, Kasinath V, Cech T
bioRxiv
. 2024 Sep;
PMID: 39257770
Methyltransferase PRC2 (Polycomb Repressive Complex 2) introduces histone H3K27 trimethylation, a repressive chromatin mark, to tune the differential expression of genes. PRC2 is precisely regulated by accessory proteins, histone post-translational...
3.
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
bioRxiv
. 2024 Feb;
PMID: 38370759
Polycomb repressive complex 2 (PRC2) is an epigenetic regulator essential for embryonic development and maintenance of cell identity that trimethylates histone H3 at lysine 27 (H3K27me3) leading to gene silencing....
4.
Song J, Gooding A, Hemphill W, Love B, Robertson A, Yao L, et al.
Science
. 2023 Sep;
381(6664):1331-1337.
PMID: 37733873
Polycomb repressive complex 2 (PRC2) silences genes through trimethylation of histone H3K27. PRC2 associates with numerous precursor messenger RNAs (pre-mRNAs) and long noncoding RNAs (lncRNAs) with a binding preference for...
5.
Song J, Gooding A, Hemphill W, Kasinath V, Cech T
bioRxiv
. 2023 Feb;
PMID: 36798278
One-sentence Summary: Cryo-EM structure of RNA-bound PRC2 dimer elucidates an unexpected mechanism of PRC2 inhibition by RNA.
6.
Jansson-Fritzberg L, Sousa C, Smallegan M, Song J, Gooding A, Kasinath V, et al.
RNA
. 2022 Dec;
29(3):346-360.
PMID: 36574982
Aberrant DNA methylation is one of the earliest hallmarks of cancer. DNMT1 is responsible for methylating newly replicated DNA, but the precise regulation of DNMT1 to ensure faithful DNA methylation...
7.
Iragavarapu A, Yao L, Kasinath V
Biochem Soc Trans
. 2021 Nov;
49(6):2639-2653.
PMID: 34747969
Polycomb repressive complexes are a family of chromatin modifier enzymes which are critical for regulating gene expression and maintaining cell-type identity. The reversible chemical modifications of histone H3 and H2A...
8.
Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, et al.
Science
. 2021 Jan;
371(6527).
PMID: 33479123
Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) cooperate to determine cell identity by epigenetic gene expression regulation. However, the mechanism of PRC2 recruitment by means of recognition of...
9.
Kasinath V, Poepsel S, Nogales E
Biochemistry
. 2018 Nov;
58(5):346-354.
PMID: 30451485
Polycomb group proteins are transcriptional repressors controlling gene expression patterns and maintaining cell type identity. The chemical modifications of histones and DNA caused by the regulated activity of chromatin-modifying enzymes...
10.
Poepsel S, Kasinath V, Nogales E
Nat Struct Mol Biol
. 2018 Jan;
25(2):154-162.
PMID: 29379173
Epigenetic regulation is mediated by protein complexes that couple recognition of chromatin marks to activity or recruitment of chromatin-modifying enzymes. Polycomb repressive complex 2 (PRC2), a gene silencer that methylates...