Wayne J Higgins
Overview
Explore the profile of Wayne J Higgins including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
72
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0
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Recent Articles
1.
Higgins W, Grehan G, Wynne K, Worrall D
Biochim Biophys Acta Proteins Proteom
. 2016 Dec;
1865(2):195-200.
PMID: 27989643
SerpinI2/Pancpin/MEPI is a 46kDa member of the serpin (serine protease inhibitor) superfamily. It is downregulated in pancreatic and breast cancer, and associated with acinar cell apoptosis and pancreatic insufficiency when...
2.
Anguissola S, McCormack W, Morrin M, Higgins W, Fox D, Worrall D
PLoS One
. 2011 Oct;
6(10):e26234.
PMID: 22028839
PEDF (Pigment epithelium-derived factor) is a non-inhibitory member of the serpin gene family (serpinF1) that displays neurotrophic and anti-angiogenic properties. PEDF contains a secretion signal sequence, but although originally regarded...
3.
de Koning P, Kummer J, de Poot S, Quadir R, Broekhuizen R, Mcgettrick A, et al.
PLoS One
. 2011 Aug;
6(8):e22645.
PMID: 21857942
Granzyme-mediated cell death is the major pathway for cytotoxic lymphocytes to kill virus-infected and tumor cells. In humans, five different granzymes (i.e. GrA, GrB, GrH, GrK, and GrM) are known...
4.
Higgins W, Fox D, Kowalski P, Nielsen J, Worrall D
J Biol Chem
. 2009 Dec;
285(6):3722-3729.
PMID: 19959474
The glycosaminoglycan heparin is known to possess antimetastatic activity in experimental models and preclinical studies, but there is still uncertainty over its mechanism of action in this respect. As an...