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Ward Ortmann

Explore the profile of Ward Ortmann including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 21
Citations 3465
Followers 0
Related Specialties
Genetics
General Medicine
Science
Top 10 Co-Authors
Timothy W Behrens
Robert R Graham
Peter K Gregersen
Ricardo C Ferreira
Lindsey A Criswell
Michael F Seldin
Tushar R Bhangale
Annette T Lee
Tushar Bhangale
Leonid Padyukov
Published In
Nat Genet
Nat Neurosci
Am J Hum Genet
N Engl J Med
Sci Transl Med
Affiliations
Soon will be listed here.
Recent Articles
1.
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders
Bryois J, Calini D, Macnair W, Foo L, Urich E, Ortmann W, et al.
Nat Neurosci . 2022 Aug; 25(8):1104-1112. PMID: 35915177
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic variants contribute to gene expression, have been performed in heterogeneous brain tissues rather than specific cell types....
2.
Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis
Owczarczyk K, Cascino M, Holweg C, Tew G, Ortmann W, Behrens T, et al.
JCI Insight . 2020 Aug; 5(18). PMID: 32841219
BACKGROUNDBaseline expression of FCRL5, a marker of naive and memory B cells, was shown to predict response to rituximab (RTX) in rheumatoid arthritis. This study investigated baseline expression of FCRL5...
3.
Previously reported placebo-response-associated variants do not predict patient outcomes in inflammatory disease Phase III trial placebo arms
Haug-Baltzell A, Bhangale T, Chang D, Dressen A, Yaspan B, Ortmann W, et al.
Genes Immun . 2018 Mar; 20(2):172-179. PMID: 29550837
In clinical trials, a placebo response refers to improvement in disease symptoms arising from the psychological effect of receiving a treatment rather than the actual treatment under investigation. Previous research...
4.
Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency
Bronson P, Chang D, Bhangale T, Seldin M, Ortmann W, Ferreira R, et al.
Nat Genet . 2016 Oct; 48(11):1425-1429. PMID: 27723758
Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Europeans. Our genome-wide association study (GWAS) meta-analysis of 1,635 patients with IgAD and 4,852 controls identified four new...
5.
Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics
Lee J, Cheng R, Vardarajan B, Lantigua R, Reyes-Dumeyer D, Ortmann W, et al.
JAMA Neurol . 2015 Jul; 72(9):1043-51. PMID: 26214276
Importance: The present study identified potential genetic modifiers that may delay or accelerate age at onset of familial Alzheimer disease (AD) by examining age at onset in PSEN1 mutation carrier...
6.
TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits
Diogo D, Bastarache L, Liao K, Graham R, Fulton R, Greenberg J, et al.
PLoS One . 2015 Apr; 10(4):e0122271. PMID: 25849893
Despite the success of genome-wide association studies (GWAS) in detecting a large number of loci for complex phenotypes such as rheumatoid arthritis (RA) susceptibility, the lack of information on the...
7.
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
Wetzel-Smith M, Hunkapiller J, Bhangale T, Srinivasan K, Maloney J, Atwal J, et al.
Nat Med . 2014 Nov; 20(12):1452-7. PMID: 25419706
We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset...
8.
Using gene expression to improve the power of genome-wide association analysis
Ho Y, Baechler E, Ortmann W, Behrens T, Graham R, Bhangale T, et al.
Hum Hered . 2014 Aug; 78(2):94-103. PMID: 25096029
Background/aims: Genome-wide association (GWA) studies have reported susceptible regions in the human genome for many common diseases and traits; however, these loci only explain a minority of trait heritability. To...
9.
Missense variant in TREML2 protects against Alzheimer's disease
Benitez B, Jin S, Guerreiro R, Graham R, Lord J, Harold D, et al.
Neurobiol Aging . 2014 Jan; 35(6):1510.e19-26. PMID: 24439484
TREM and TREM-like receptors are a structurally similar protein family encoded by genes clustered on chromosome 6p21.11. Recent studies have identified a rare coding variant (p.R47H) in TREM2 that confers...
10.
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, et al.
Nature . 2014 Jan; 506(7488):376-81. PMID: 24390342
A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets to provide insight into disease pathogenesis and...