Wangzhen Shen
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Explore the profile of Wangzhen Shen including associated specialties, affiliations and a list of published articles.
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49
Citations
1024
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Recent Articles
1.
DeLeeuw M, Shen W, Tian X, Ding C, Randhave K, Kang J
Epilepsy Res
. 2025 Feb;
210:107514.
PMID: 39923323
Background: Haploinsufficient deletions of GABA transporter 1 (GAT-1)- encoding SLC6A1, and GABA transporter 3 (GAT-3)-encoding SLC6A11 are implicated in epileptic syndromes. Despite their significance, the impact of these deletions has...
2.
Poliquin S, Nwosu G, Randhave K, Shen W, Flamm C, Kang J
Int J Mol Sci
. 2024 May;
25(9).
PMID: 38731820
A significant number of patients with genetic epilepsy do not obtain seizure freedom, despite developments in new antiseizure drugs, suggesting a need for novel therapeutic approaches. Many genetic epilepsies are...
3.
Shen W, Nwosu G, Honer M, Clasadonte J, Schmalzbauer S, Biven M, et al.
Brain Commun
. 2024 Apr;
6(2):fcae110.
PMID: 38650830
We have previously characterized the molecular mechanisms for variants in γ-aminobutyric acid transporter 1-encoding solute carrier family 6-member 1 () and concluded that a partial or complete loss of γ-aminobutyric...
4.
Hernandez C, Hu N, Shen W, Macdonald R
Biomolecules
. 2023 Dec;
13(12).
PMID: 38136660
Variants in the gene, which encodes the β subunit of the GABA receptor, have been implicated in various epileptic encephalopathies and related neurodevelopmental disorders such as Dravet syndrome and Angelman...
5.
Shen W, Flamm C, Delahanty A, Casteel E, Biven M, DeLeeuw M, et al.
Epilepsia
. 2023 Sep;
65(1):204-217.
PMID: 37746768
Objective: γ-Aminobutyric acid type A (GABA ) receptor subunit gene mutations are major causes of various epilepsy syndromes, including severe kinds such as Dravet syndrome. Although the GABA receptor is...
6.
Zhang Q, Forster-Gibson C, Bercovici E, Bernardo A, Ding F, Shen W, et al.
Exp Neurol
. 2023 Sep;
369:114537.
PMID: 37703949
Objective: GABA receptor subunit gene (GABR) mutations are significant causes of epilepsy, including syndromic epilepsy. This report for the first time, describes intractable epilepsy and blindness due to optic atrophy...
7.
Zhang J, Zhu C, Jin Y, Shen W, Pan Y, Shen Y
Biochem Biophys Res Commun
. 2023 Jul;
675:26-32.
PMID: 37451214
Objective: This research was devoted to estimating the outcomes of ginsenoside Rg1 on learning and memory ability and neuronal apoptosis in epileptic rats through ERK/CREB/BDNF pathway. Methods: The epileptic rats...
8.
Nwosu G, Shen W, Zavalin K, Poliquin S, Randhave K, Flamm C, et al.
Int J Mol Sci
. 2023 May;
24(9).
PMID: 37176165
Lennox-Gastaut Syndrome (LGS) is a developmental and epileptic encephalopathy (DEE) characterized by multiple seizure types, electroencephalogram (EEG) patterns, and cognitive decline. Its etiology has a prominent genetic component, including variants...
9.
Hernandez C, Shen Y, Hu N, Shen W, Narayanan V, Ramsey K, et al.
Biomolecules
. 2023 Mar;
13(3).
PMID: 36979350
Febrile seizures (FS) are the most common form of epilepsy in children between six months and five years of age. FS is a self-limited type of fever-related seizure. However, complicated...
10.
Qu S, Jackson L, Zhou C, Shen D, Shen W, Nwosu G, et al.
Epilepsia
. 2022 Dec;
64(4):1061-1073.
PMID: 36495145
Objective: Infantile spasms is an epileptic encephalopathy of childhood, and its pathophysiology is largely unknown. We generated a heterozygous knock-in mouse with the human infantile spasms-associated de novo mutation GABRB3...