Sarah Poliquin
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Explore the profile of Sarah Poliquin including associated specialties, affiliations and a list of published articles.
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14
Citations
173
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Recent Articles
1.
Pullen L, Bott N, McCanless C, Revana A, Sevinc G, Gorman C, et al.
Clocks Sleep
. 2024 Nov;
6(4):656-667.
PMID: 39584973
The need for sleep is universal, and the ability to meet this need impacts the quality of life for patients, families, and caregivers. Although substantial progress has been made in...
2.
Poliquin S, Nwosu G, Randhave K, Shen W, Flamm C, Kang J
Int J Mol Sci
. 2024 May;
25(9).
PMID: 38731820
A significant number of patients with genetic epilepsy do not obtain seizure freedom, despite developments in new antiseizure drugs, suggesting a need for novel therapeutic approaches. Many genetic epilepsies are...
3.
Shen W, Nwosu G, Honer M, Clasadonte J, Schmalzbauer S, Biven M, et al.
Brain Commun
. 2024 Apr;
6(2):fcae110.
PMID: 38650830
We have previously characterized the molecular mechanisms for variants in γ-aminobutyric acid transporter 1-encoding solute carrier family 6-member 1 () and concluded that a partial or complete loss of γ-aminobutyric...
4.
Shen W, Flamm C, Delahanty A, Casteel E, Biven M, DeLeeuw M, et al.
Epilepsia
. 2023 Sep;
65(1):204-217.
PMID: 37746768
Objective: γ-Aminobutyric acid type A (GABA ) receptor subunit gene mutations are major causes of various epilepsy syndromes, including severe kinds such as Dravet syndrome. Although the GABA receptor is...
5.
Nwosu G, Shen W, Zavalin K, Poliquin S, Randhave K, Flamm C, et al.
Int J Mol Sci
. 2023 May;
24(9).
PMID: 37176165
Lennox-Gastaut Syndrome (LGS) is a developmental and epileptic encephalopathy (DEE) characterized by multiple seizure types, electroencephalogram (EEG) patterns, and cognitive decline. Its etiology has a prominent genetic component, including variants...
6.
Nwosu G, Mermer F, Flamm C, Poliquin S, Shen W, Rigsby K, et al.
Brain Commun
. 2022 Aug;
4(3):fcac144.
PMID: 35911425
We have studied the molecular mechanisms of variants in solute carrier Family 6 Member 1 associated with neurodevelopmental disorders, including various epilepsy syndromes, autism and intellectual disability. Based on functional...
7.
Mermer F, Poliquin S, Zhou S, Wang X, Ding Y, Yin F, et al.
Neurobiol Dis
. 2022 Jul;
172:105810.
PMID: 35840120
Objective: Mutations in γ-aminobutyric acid (GABA) transporter 1 (GAT-1)-encoding SLC6A1 have been associated with myoclonic atonic epilepsy and other phenotypes. We determined the patho-mechanisms of the mutant GAT-1, in order...
8.
Poliquin S, Kang J
Biomedicines
. 2022 Mar;
10(3).
PMID: 35327449
The epilepsies are a broad group of conditions characterized by repeated seizures, and together are one of the most common neurological disorders. Additionally, epilepsy is comorbid with many neurological disorders,...
9.
Mermer F, Poliquin S, Rigsby K, Rastogi A, Shen W, Romero-Morales A, et al.
Brain
. 2021 May;
144(8):2499-2512.
PMID: 34028503
Solute carrier family 6 member 1 (SLC6A1) is abundantly expressed in the developing brain even before the CNS is formed. Its encoded GABA transporter 1 (GAT-1) is responsible for the...
10.
Poliquin S, Hughes I, Shen W, Mermer F, Wang J, Mack T, et al.
Exp Neurol
. 2021 May;
342:113723.
PMID: 33961861
Background: Mutations in SLC6A1, encoding γ-aminobutyric acid (GABA) transporter 1 (GAT-1), have been recently associated with a spectrum of neurodevelopmental disorders ranging from variable epilepsy syndromes, intellectual disability (ID), autism...