Wan Hsi Chen
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Explore the profile of Wan Hsi Chen including associated specialties, affiliations and a list of published articles.
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6
Citations
57
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Recent Articles
1.
Schell J, Wei S, Zhang J, Trevino Jr R, Chen W, Aguilar L, et al.
Free Radic Biol Med
. 2025 Jan;
229:58-67.
PMID: 39824446
Manganese superoxide dismutase (MnSOD/SOD2) is an essential mitochondrial enzyme that detoxifies superoxide radicals generated during oxidative respiration. MnSOD/SOD2 lysine 68 acetylation (K68-Ac) is an important post-translational modification (PTM) that regulates...
2.
Zhang Q, Litwin C, Dietert K, Tsialtas I, Chen W, Li Z, et al.
J Biol Rhythms
. 2025 Jan;
:7487304241311328.
PMID: 39773136
Circadian disruption is pervasive in modern society and associated with increased risk of disease. Chronic jet lag paradigms are popular experimental tools aiming to emulate human circadian disruption experienced during...
3.
Wei S, Schell J, Chocron E, Varmazyad M, Xu G, Chen W, et al.
Sci Adv
. 2024 May;
10(20):eado1463.
PMID: 38758782
A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of ketones. While KDs improve certain health conditions and are popular for weight loss, detrimental effects...
4.
Smith J, Molendijk J, Blazev R, Chen W, Zhang Q, Litwin C, et al.
Mol Cell Proteomics
. 2023 Oct;
22(11):100655.
PMID: 37793502
Molecular clocks and daily feeding cycles support metabolism in peripheral tissues. Although the roles of local clocks and feeding are well defined at the transcriptional level, their impact on governing...
5.
Koneru B, Farooqi A, Nguyen T, Chen W, Hindle A, Eslinger C, et al.
Sci Transl Med
. 2021 Aug;
13(607).
PMID: 34408079
Cancers overcome replicative immortality by activating either telomerase or an alternative lengthening of telomeres (ALT) mechanism. ALT occurs in ~25% of high-risk neuroblastomas, and progression in patients with ALT neuroblastoma...
6.
Hindle A, Koneru B, Makena M, Lopez-Barcons L, Chen W, Nguyen T, et al.
Anticancer Drugs
. 2020 Dec;
32(3):233-247.
PMID: 33323683
DNA-damaging chemotherapy is a major component of therapy for high-risk neuroblastoma, and patients often relapse with treatment-refractory disease. We hypothesized that DNA repair genes with increased expression in alkylating agent...
7.
Nguyen T, Koneru B, Wei S, Chen W, Makena M, Urias E, et al.
Mol Cancer Ther
. 2019 Sep;
18(12):2270-2282.
PMID: 31484706
Recurrent high-risk neuroblastoma is a childhood cancer that often fails to respond to therapy. Fenretinide (4-HPR) is a cytotoxic retinoid with clinical activity in recurrent neuroblastoma and venetoclax (ABT-199) is...