Waipan Chan
Overview
Explore the profile of Waipan Chan including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
367
Followers
0
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Recent Articles
1.
Gottlieb S, Shang W, Ye D, Kubo S, Jiang P, Shafer S, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(44):e2416722121.
PMID: 39436665
T cell receptor (TCR) engagement causes a global cellular response that entrains signaling pathways, cell cycle regulation, and cell death. The molecular regulation of mRNA translation in these processes is...
2.
Chan W, Cao Y, Zhao X, Schrom E, Jia D, Song J, et al.
J Exp Med
. 2023 Oct;
220(12).
PMID: 37796477
Checkpoint blockade revolutionized cancer therapy, but we still lack a quantitative, mechanistic understanding of how inhibitory receptors affect diverse signaling pathways. To address this issue, we developed and applied a...
3.
Kubo S, Kataria R, Yao Y, Gabrielski J, Zheng L, Markowitz T, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(33):e2208522119.
PMID: 35939714
Apoptosis is a genetically regulated program of cell death that plays a key role in immune disease processes. We identified EBF4, a little-studied member of the early B cell factor...
4.
Zhao X, Kolawole E, Chan W, Feng Y, Yang X, Gee M, et al.
Science
. 2022 Apr;
376(6589):eabl5282.
PMID: 35389803
Adoptive cell therapy using engineered T cell receptors (TCRs) is a promising approach for targeting cancer antigens, but tumor-reactive TCRs are often weakly responsive to their target ligands, peptide-major histocompatibility...
5.
Dong R, Aksel T, Chan W, Germain R, Vale R, Douglas S
Proc Natl Acad Sci U S A
. 2021 Sep;
118(40).
PMID: 34588308
Receptor clustering plays a key role in triggering cellular activation, but the relationship between the spatial configuration of clusters and the elicitation of downstream intracellular signals remains poorly understood. We...
6.
Chan W, Gottschalk R, Yao Y, Pomerantz J, Germain R
Immunohorizons
. 2021 Feb;
5(2):117-132.
PMID: 33622708
Clustered regularly interspaced short palindromic repeats (CRISPR)-based methods have revolutionized genome engineering and the study of gene-phenotype relationships. However, modifying cells of the innate immune system, especially macrophages, has been...
7.
Gottschalk R, Dorrington M, Dutta B, Krauss K, Martins A, Uderhardt S, et al.
Elife
. 2019 Aug;
8.
PMID: 31385572
Despite existing evidence for tuning of innate immunity to different classes of bacteria, the molecular mechanisms used by macrophages to tailor inflammatory responses to specific pathogens remain incompletely defined. By...
8.
Yang Y, Yang C, Chan W, Wang Z, Deibel K, Pomerantz J
J Biol Chem
. 2016 Oct;
291(50):25921-25936.
PMID: 27777308
The activation of NF-κB downstream of T cell receptor (TCR) engagement is a key signaling step required for normal lymphocyte function during the adaptive immune response. During TCR signaling, the...
9.
Pedersen S, Chan W, Jattani R, Mackie D, Pomerantz J
Mol Cell Biol
. 2016 Apr;
36(8):1322.
PMID: 27034408
No abstract available.
10.
Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181
Pedersen S, Chan W, Jattani R, Mackie D, Pomerantz J
Mol Cell Biol
. 2015 Dec;
36(5):794-808.
PMID: 26711259
NF-κB activation downstream of antigen receptor engagement is a highly regulated event required for lymphocyte activation during the adaptive immune response. The pathway is often dysregulated in lymphoma, leading to...