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» Authors » Wael A El-Sayed

Wael A El-Sayed

Explore the profile of Wael A El-Sayed including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 42
Citations 237
Followers 0
Related Specialties
Biology
Biochemistry
Molecular Biology
Top 10 Co-Authors
Adel A-H Abdel-Rahman
Hanem M Awad
Eman S Nossier
Omar M Ali
Ibrahim F Nassar
Ashraf M Mohamed
Asmaa F Kassem
Sayed M Saleh
Mohamed N El-Bayaa
Fahad M Alminderej
Published In
Z Naturforsch C J Biosci
Molecules
Acta Pol Pharm
Nucleosides Nucleotides Nucleic Acids
Arch Pharm (Weinheim)
Affiliations
Soon will be listed here.
Recent Articles
1.
Novel quinazolin-4-one based derivatives bearing 1,2,3-triazole and glycoside moieties as potential cytotoxic agents through dual EGFR and VEGFR-2 inhibitory activity
Abdel-Rahman A, El-Bayaa M, Sobhy A, El-Ganzoury E, Nossier E, Awad H, et al.
Sci Rep . 2024 Oct; 14(1):24980. PMID: 39443462
The toxicity that was caused by the developed medications for anticancer treatment is, unfortunately, an earnest problem stemming from the various involved targets, and accordingly, intense research for overcoming such...
2.
Design, Synthesis, Anticancer Activity and Molecular Docking of New 1,2,3-Triazole-Based Glycosides Bearing 1,3,4-Thiadiazolyl, Indolyl and Arylacetamide Scaffolds
Elganzory H, M Alminderej F, El-Bayaa M, Awad H, Nossier E, El-Sayed W
Molecules . 2022 Oct; 27(20). PMID: 36296551
New 1,3,4-thiadiazole thioglycosides linked to a substituted arylidine system were synthesized via heterocyclization via click 1,3-dipolar cycloaddition. The click strategy was used for the synthesis of new 1,3,4-thiadiazole and 1,2,3-triazole...
3.
New 1,2,3-Triazole-Coumarin-Glycoside Hybrids and Their 1,2,4-Triazolyl Thioglycoside Analogs Targeting Mitochondria Apoptotic Pathway: Synthesis, Anticancer Activity and Docking Simulation
El-Sayed W, M Alminderej F, Mounier M, Nossier E, M Saleh S, Kassem A
Molecules . 2022 Sep; 27(17). PMID: 36080455
Toxicity and resistance to newly synthesized anticancer drugs represent a challenging phenomenon of intensified concern arising from variation in drug targets and consequently the prevalence of the latter concern requires...
4.
Synthesis, biological evaluation, and studies of new CDK2 inhibitors based on pyrazolo[3,4-]pyrimidine and pyrazolo[4,3-][1,2,4]triazolo[1,5-]pyrimidine scaffold with apoptotic activity
Mandour A, Nassar I, Abdel Aal M, Shahin M, El-Sayed W, Hegazy M, et al.
J Enzyme Inhib Med Chem . 2022 Jul; 37(1):1957-1973. PMID: 35815597
Cyclin-dependent kinase inhibition is considered a promising target for cancer treatment for its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established for their antitumor activity via...
5.
Microwave-Assisted Rapid Synthesis of Luminescent Tryptophan-Stabilized Silver Nanoclusters for Ultra-Sensitive Detection of Fe(III), and Their Application in a Test Strip
M Saleh S, El-Sayed W, El-Manawaty M, Gassoumi M, Ali R
Biosensors (Basel) . 2022 Jun; 12(6). PMID: 35735572
A new preparation method for extreme fluorescent green emission tryptophan-stabilized silver nanoclusters (Tryp-AgNCs) is presented in this scientific research. The produced silver nanoclusters are dependent on tryptophan amino acid which...
6.
Discovery of pyrazolo[3,4-]pyrimidine and pyrazolo[4,3-][1,2,4]triazolo[1,5-]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations
Nassar I, Abdel Aal M, El-Sayed W, Shahin M, Elsakka E, Mokhtar M, et al.
RSC Adv . 2022 Jun; 12(23):14865-14882. PMID: 35702208
CDK2 inhibition is an appealing target for cancer treatment that targets tumor cells in a selective manner. A new set of small molecules featuring the privileged pyrazolo[3,4-]pyrimidine and pyrazolo[4,3-][1,2,4]triazolo[1,5-]pyrimidine scaffolds...
7.
An Eco-Friendly Synthetic Approach for Copper Nanoclusters and Their Potential in Lead Ions Sensing and Biological Applications
M Saleh S, El-Sayed W, El-Manawaty M, Gassoumi M, Ali R
Biosensors (Basel) . 2022 Apr; 12(4). PMID: 35448257
A new preparation route for high-luminescent blue-emission pepsin copper nanoclusters (Pep-CuNCs) is introduced in this work. The synthesized nanoclusters are based on a pepsin molecule, which is a stomach enzyme...
8.
Novel 1,2,3-Triazole-Coumarin Hybrid Glycosides and Their Tetrazolyl Analogues: Design, Anticancer Evaluation and Molecular Docking Targeting EGFR, VEGFR-2 and CDK-2
El-Sayed W, M Alminderej F, Mounier M, Nossier E, M Saleh S, Kassem A
Molecules . 2022 Apr; 27(7). PMID: 35408446
This study represents the design and synthesis of a new set of triazole-coumarin-glycosyl hybrids and their tetrazole hybrid analogues possessing various sugar moieties and modified analogues. All the newly synthesized...
9.
In Vitro and In Vivo Antiviral Studies of New Heteroannulated 1,2,3-Triazole Glycosides Targeting the Neuraminidase of Influenza A Viruses
Kutkat O, Kandeil A, Moatasim Y, Elshaier Y, El-Sayed W, Gaballah S, et al.
Pharmaceuticals (Basel) . 2022 Mar; 15(3). PMID: 35337148
There is an urgent need to develop and synthesize new anti-influenza drugs with activity against different strains, resistance to mutations, and suitability for various populations. Herein, we tested in vitro...
10.
The Effect of AlI Nanoadditive on the Thermal Behavior of PMMA Subjected to Thermoanalytical Py-GC-MS Technique
Adnan M, Rahman T, Bahadur A, Zeb M, Liaqat W, Akitsu T, et al.
Materials (Basel) . 2021 Nov; 14(22). PMID: 34832436
Thermal degradation of polymethylmethacrylate (PMMA) was studied by using inorganic salt of aluminum triiodide (AlI). The composites of PMMA were prepared with AlI by changing the concentration of the AlI...