Wa Du
Overview
Explore the profile of Wa Du including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
18
Citations
578
Followers
0
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Recent Articles
11.
Cui H, Okamoto Y, Yoshioka K, Du W, Takuwa N, Zhang W, et al.
J Allergy Clin Immunol
. 2013 Sep;
132(5):1205-1214.e9.
PMID: 24021572
Background: Sphingosine-1-phosphate receptor 2 (S1P(2)) is expressed in vascular endothelial cells (ECs). However, the role of S1P(2) in vascular barrier integrity and anaphylaxis is not well understood. Endothelial nitric oxide...
12.
Du W, Gerald D, Perruzzi C, Rodriguez-Waitkus P, Enayati L, Krishnan B, et al.
Lab Invest
. 2013 Aug;
93(10):1115-27.
PMID: 23938603
Vascular tumors are endothelial cell neoplasms whose cellular and molecular mechanisms, leading to tumor formation, are poorly understood, and current therapies have limited efficacy with significant side effects. We have...
13.
Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, et al.
Nat Med
. 2012 Sep;
18(10):1560-9.
PMID: 22983395
The class II α-isoform of phosphatidylinositol 3-kinase (PI3K-C2α) is localized in endosomes, the trans-Golgi network and clathrin-coated vesicles; however, its functional role is not well understood. Global or endothelial-cell-specific deficiency...
14.
Takuwa N, Du W, Kaneko E, Okamoto Y, Yoshioka K, Takuwa Y
Am J Cancer Res
. 2011 Oct;
1(4):460-81.
PMID: 21984966
Sphingosine-1-phosphate (S1P) is a plasma lipid mediator with multiple roles in mammalian development, physiology and pathophysiology. It is constitutively produced mostly by erythrocytes by the action of sphingosine kinase 1...
15.
Takuwa Y, Du W, Qi X, Okamoto Y, Takuwa N, Yoshioka K
World J Biol Chem
. 2011 May;
1(10):298-306.
PMID: 21537463
Sphingosine-1-phosphate (S1P) is a blood-borne lipid mediator with pleiotropic biological activities. S1P acts via the specific cell surface G-protein-coupled receptors, S1P(1-5). S1P(1) and S1P(2) were originally identified from vascular endothelial...
16.
Wang F, Okamoto Y, Inoki I, Yoshioka K, Du W, Qi X, et al.
J Clin Invest
. 2010 Oct;
120(11):3979-95.
PMID: 20978351
Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid that has pleiotropic effects in a variety of cell types including ECs, SMCs, and macrophages, all of which are central to the development...
17.
Qi X, Okamoto Y, Murakawa T, Wang F, Oyama O, Ohkawa R, et al.
Eur J Pharmacol
. 2010 Mar;
634(1-3):121-31.
PMID: 20206620
Therapeutic angiogenesis is a promising strategy for treating ischemia. The lysophospholipid mediator sphingosine-1-phosphate (S1P) acts on vascular endothelial cells to stimulate migration and tube formation, and plays the critical role...
18.
Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, et al.
Cancer Res
. 2010 Jan;
70(2):772-81.
PMID: 20068174
Sphingosine-1-phosphate (S1P) has been implicated in tumor angiogenesis by acting through the G(i)-coupled chemotactic receptor S1P(1). Here, we report that the distinct receptor S1P(2) is responsible for mediating the G(12/13)/Rho-dependent...
19.
Takuwa N, Ohkura S, Takashima S, Ohtani K, Okamoto Y, Tanaka T, et al.
Cardiovasc Res
. 2009 Sep;
85(3):484-93.
PMID: 19755413
Aims: Sphingosine kinase 1 (SPHK1), its product sphingosine-1-phosphate (S1P), and S1P receptor subtypes have been suggested to play protective roles for cardiomyocytes in animal models of ischaemic preconditioning and cardiac...