W R Pearson
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Explore the profile of W R Pearson including associated specialties, affiliations and a list of published articles.
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57
Citations
7014
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Recent Articles
1.
Reese J, Pearson W
Bioinformatics
. 2002 Nov;
18(11):1500-7.
PMID: 12424122
Motivation: No general theory guides the selection of gap penalties for local sequence alignment. We empirically determined the most effective gap penalties for protein sequence similarity searches with substitution matrices...
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Pearson W
Methods Mol Biol
. 1999 Nov;
132:185-219.
PMID: 10547837
The FASTA3 and FASTA2 packages provide a flexible set of sequence-comparison programs that are particularly valuable because of their accurate statistical estimates and high-quality alignments. Traditionally, sequence similarity searches have...
4.
Wood T, Pearson W
J Mol Biol
. 1999 Aug;
291(4):977-95.
PMID: 10452901
The relationship between sequence similarity and structural similarity has been examined in 36 protein families with five or more diverse members whose structures are known. The structural similarity within a...
5.
Pearson W, Robins G, Zhang T
Mol Biol Evol
. 1999 Jun;
16(6):806-16.
PMID: 10368958
We have developed a phylogenetic tree reconstruction method that detects and reports multiple topologically distant low-cost solutions. Our method is a generalization of the neighbor-joining method of Saitou and Nei...
6.
Retief J, Lynch K, Pearson W
Genome Res
. 1999 Apr;
9(4):373-82.
PMID: 10207159
We have developed a rapid visual method for identifying novel members of gene families. Starting with an evolutionary tree, 20-50 protein query sequences for a gene family are selected from...
7.
Patskovsky Y, Huang M, Takayama T, Listowsky I, Pearson W
Arch Biochem Biophys
. 1999 Jan;
361(1):85-93.
PMID: 9882431
The sequence and exon-intron structure of the human class mu GSTM3 glutathione transferase gene and its orientation with respect to the remainder of the human class mu GSTM gene cluster...
8.
Damer C, Partridge J, Pearson W, Haystead T
J Biol Chem
. 1998 Sep;
273(38):24396-405.
PMID: 9733729
Microcystin-affinity chromatography was used to purify 15 protein phosphatase 1 (PP1)-binding proteins from the myofibrillar fraction of rabbit skeletal muscle. To reduce the time and amount of material required to...
9.
Pearson W
J Mol Biol
. 1998 Mar;
276(1):71-84.
PMID: 9514730
The FASTA package of sequence comparison programs has been modified to provide accurate statistical estimates for local sequence similarity scores with gaps. These estimates are derived using the extreme value...
10.
Characterization of the human class Mu glutathione S-transferase gene cluster and the GSTM1 deletion
Xu S, Wang Y, Roe B, Pearson W
J Biol Chem
. 1998 Mar;
273(6):3517-27.
PMID: 9452477
A partial physical map has been constructed of the human class Mu glutathione S-transferase genes on chromosome 1p13.3. The glutathione S-transferase genes in this cluster are spaced about 20 kilobase...