W R Osborne
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Explore the profile of W R Osborne including associated specialties, affiliations and a list of published articles.
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62
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657
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Recent Articles
1.
Seppen J, Barry S, Harder B, Osborne W
Blood
. 2001 Jul;
98(3):594-6.
PMID: 11468155
A lentivirus pseudotyped with vesicular stomatitis virus G protein (VSV-G) encoding rat erythropoietin (EPO) complementary DNA was administered to rat skeletal muscle and red blood cell production was serially monitored....
2.
Barry S, Harder B, Brzezinski M, Flint L, Seppen J, Osborne W
Hum Gene Ther
. 2001 Jun;
12(9):1103-8.
PMID: 11399231
Incorporation of a central polypurine tract (cPPT) and a posttranscriptional regulatory element (PRE) into lentivirus vectors provides increased transduction efficiency and transgene expression. We compared the effects of these elements...
3.
Barry S, Ramesh N, Lejnieks D, Simonson W, KEMPER L, Lernmark A, et al.
Hum Gene Ther
. 2001 Feb;
12(2):131-9.
PMID: 11177550
Retroviral vectors encoding glucose-responsive promoters driving furin expression may provide an amplified, glucose-regulated secretion of insulin. We constructed LhI*TFSN virus to encode a glucose-regulatable transforming growth factor alpha promoter controlling...
4.
Seppen J, Barry S, Klinkspoor J, Katen L, Lee S, Garcia J, et al.
J Virol
. 2000 Jul;
74(16):7642-5.
PMID: 10906219
Intestinal epithelial cells secrete a protective luminal mucus barrier inhibiting viral gene transfer. Quiescent, polarized monolayers of primary epithelial cells from dog gallbladder and human colon are efficiently transduced through...
5.
Seppen J, Barry S, Lam G, Ramesh N, Osborne W
Hum Gene Ther
. 2000 Apr;
11(5):771-5.
PMID: 10757356
Obtaining high expression levels of a therapeutic gene in target cells could be achieved by integrating multiple copies of a recombinant retrovirus. However, we observed that cells retrovirally infected at...
6.
Barry S, Seppen J, Ramesh N, Foster J, Seyama K, Ochs H, et al.
Hum Gene Ther
. 2000 Feb;
11(2):323-32.
PMID: 10680845
Efficient transduction of primary human T cells is an important goal toward treating a number of genetic defects. Patient T cells could be harvested by leukapheresis, transduced, and returned to...
7.
Kuver R, Klinkspoor J, Osborne W, Lee S
Glycobiology
. 2000 Jan;
10(2):149-57.
PMID: 10642606
A mechanistic model of mucous granule exocytosis by columnar epithelial cells must take into account the unique physical-chemical properties of mucin glycoproteins and the resultant mucus gel. In particular, any...
8.
Wei M, Lejnieks D, Ramesh N, Lau S, Seppen J, Osborne W
Gene Ther
. 1999 Oct;
6(5):840-4.
PMID: 10505109
Retrovirus-mediated gene transfer into adult skin fibroblasts has provided measurable amounts of therapeutic proteins in animal models. However, the major problem emerging from these experiments was a limited time of...
9.
CD40 ligand mutants responsible for X-linked hyper-IgM syndrome associate with wild type CD40 ligand
Seyama K, Osborne W, Ochs H
J Biol Chem
. 1999 Apr;
274(16):11310-20.
PMID: 10196221
CD40 ligand (CD40L) is a 33-kDa type II membrane glycoprotein mainly expressed on activated CD4(+) T cells in trimeric form. When it is mutated, the clinical consequences are X-linked hyper-IgM...
10.
Lejnieks D, Ramesh N, Lau S, Osborne W
Blood
. 1998 Jul;
92(3):888-93.
PMID: 9680356
To approach the goal of consistent long-term erythropoietin (Epo) expression in vivo, we developed an implantation procedure in which transduced autologous vascular smooth muscle was introduced into rats in a...