W Mark Abbott
Overview
Explore the profile of W Mark Abbott including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
289
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Recent Articles
1.
Mazharian A, Bertin O, Sarkar A, Augros J, Bornert A, Loubiere C, et al.
bioRxiv
. 2024 May;
PMID: 38798354
Platelets are highly reactive fragments of megakaryocytes that play a fundamental role in thrombosis and hemostasis. Predictably, all conventional anti-platelet therapies elicit bleeding, raising the question whether the thrombotic activity...
2.
Phelan T, Dunne J, Conlon N, Ni Cheallaigh C, Abbott W, Faba-Rodriguez R, et al.
Viruses
. 2021 Aug;
13(7).
PMID: 34372581
Serological assays have been widely employed during the coronavirus disease 2019 (COVID-19) pandemic to measure antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to track seroconversion in...
3.
Vogtle T, Sharma S, Mori J, Nagy Z, Semeniak D, Scandola C, et al.
Elife
. 2019 Aug;
8.
PMID: 31436532
The immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor G6b-B is critical for platelet production and activation. Loss of G6b-B results in severe macrothrombocytopenia, myelofibrosis and aberrant platelet function in mice and...
4.
Hussain H, Fisher D, Roth R, Abbott W, Carballo-Amador M, Warwicker J, et al.
FEBS Lett
. 2018 Jun;
592(14):2499-2511.
PMID: 29933498
Due in part to the needs of the biopharmaceutical industry, there has been an increased drive to generate high quality recombinant proteins in large amounts. However, achieving high yields can...
5.
Mckenzie E, Abbott W
Methods
. 2018 May;
147:40-49.
PMID: 29778647
Purified recombinant proteins are key reagents in academic and industrial research. The ability to make these proteins quickly often relies on the availability of higher eukaryotic cell hosts such as...
6.
Hussain H, Fisher D, Abbott W, Roth R, Dickson A
Biotechnol Bioeng
. 2017 Jun;
114(10):2348-2359.
PMID: 28627739
Certain recombinant proteins are deemed "difficult to express" in mammalian expression systems requiring significant cell and/or process engineering to abrogate expression bottlenecks. With increasing demand for the production of recombinant...
7.
Exell J, Thompson M, Finger L, Shaw S, Debreczeni J, Ward T, et al.
Nat Chem Biol
. 2016 Aug;
12(10):815-21.
PMID: 27526030
The structure-specific nuclease human flap endonuclease-1 (hFEN1) plays a key role in DNA replication and repair and may be of interest as an oncology target. We present the crystal structure...
8.
Abbott W, Middleton B, Kartberg F, Claesson J, Roth R, Fisher D
Protein Expr Purif
. 2015 Aug;
116:113-9.
PMID: 26291269
Transient expression of heterologous proteins in mammalian systems is a powerful way to generate protein reagents quickly. However, it has historically suffered from poor yields in comparison to methods where...
9.
Abbott W, Damschroder M, Lowe D
Immunology
. 2014 Mar;
142(4):526-35.
PMID: 24635566
A number of different methods are commonly used to map the fine details of the interaction between an antigen and an antibody. Undoubtedly the method that is now most commonly...
10.
Abbott W, Snow M, Eckersley S, Renshaw J, Davies G, Norman R, et al.
Biosci Rep
. 2013 Jul;
33(4).
PMID: 23863106
TNFα (tumour necrosis factor α) is an early mediator in the systemic inflammatory response to infection and is therefore a therapeutic target in sepsis. AZD9773 is an ovine-derived, polyclonal anti-TNFα...