» Authors » W M Bryan

W M Bryan

Explore the profile of W M Bryan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 41
Followers 0
Related Specialties
Top 10 Co-Authors
Published In
Affiliations
Soon will be listed here.
Recent Articles
1.
Albrightson C, Dytko G, Bryan W, Hoyle K, Moore M, Stadel J
Cell Signal . 1994 Sep; 6(7):743-50. PMID: 7888301
Thrombin stimulates cytosolic calcium mobilization and tritiated thymidine incorporation in rat glomerular mesangial cells. This effect may be mediated by a thrombin receptor similar to the receptor found in human...
2.
Brickson B, Brooks D, Bryan W, Caldwell N, Kinter L, Moore M, et al.
J Pharmacol Exp Ther . 1991 Jan; 256(1):335-40. PMID: 1988664
A series of vasopressin analogs with various amino acid tail modifications were tested for antidiuretic agonist and antagonist (water diuretic) activity in the water-loaded indomethacin-treated and hydropenic dogs, respectively. Changing...
3.
Bryan W
Methods Enzymol . 1991 Jan; 202:436-48. PMID: 1838399
No abstract available.
4.
Moore M, Bryan W, Fakhoury S, Magaard V, Huffman W, Dayton B, et al.
Biochem Biophys Res Commun . 1989 Mar; 159(2):420-5. PMID: 2649094
Oligopeptides containing the consensus retroviral protease cleavage sequence Ser/Thr-X-Y-Tyr/Phe-Pro are substrates for purified recombinant HIV-1 protease with Km's in the millimolar range. The minimum sequence containing the consensus pentapeptide which...
5.
Bryan W, Callahan J, Codd E, Lemieux C, Moore M, Schiller P, et al.
J Med Chem . 1989 Feb; 32(2):302-4. PMID: 2536436
Analogues of the highly potent and delta-receptor-selective enkephalins 1-4 were prepared with alpha-amino-beta-mercapto-beta,beta-pentamethylenepropionic acid (Apmp) replacing the beta,beta-dimethylcysteine (Pen) at positions 2 or 5. The peptides 5-8 were prepared by...
6.
Callahan J, BRYAN H, Bryan W, Heckman G, Kinter L, McDonald J, et al.
J Med Chem . 1989 Feb; 32(2):391-6. PMID: 2521519
We report the synthesis and biological activity of a series of analogues of the vasopressin antagonists [Pmp1,D-Tyr(Et)2,Val4]arginine-vasopressin (1) and [Pmp1,D-Tyr(Et)2,Val4,desGly9]arginine-vasopressin (2), where part or all of the tripeptide tail has...
7.
Bryan W, Hempel J, Huffman W, Marshall G, Moore M, Silvestri J, et al.
J Med Chem . 1988 Apr; 31(4):742-4. PMID: 2965243
Our molecular modeling studies suggested that the conformational effects of the "cystine-line" residue Pmp1-Cys6 on the cyclohexapeptide ring of the vasopressin antagonist [Pmp1,D-Phe2,Val4]AVP might be mimicked by substitution of D-aminoadipic...
8.
Huffman W, Ali F, Bryan W, Callahan J, Moore M, Silvestri J, et al.
J Med Chem . 1985 Dec; 28(12):1759-60. PMID: 2933517
No abstract available.
9.
DeMarinis R, Bryan W, Shah D, Hieble J, Pendleton R
J Med Chem . 1981 Dec; 24(12):1432-7. PMID: 6118438
A series of phenylethylamines related to methoxamine has been prepared and evaluated for direct alpha 1-receptor agonist activity. It has been observed that for open-chain compounds such as methoxamine, in...
10.
DeMarinis R, Bryan W, Hillegass L, McDermott D, Pendleton R
J Med Chem . 1981 Jun; 24(6):756-9. PMID: 7252985
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SK&F 64139) is a potent inhibitor of phenylethanolamine N-methyltransferase (IC50 = 10 muM) that may have therapeutic utility in man. A series of related compounds in which two 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline...