R M DeMarinis
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Explore the profile of R M DeMarinis including associated specialties, affiliations and a list of published articles.
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40
Citations
155
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Recent Articles
1.
Hieble J, Sulpizio A, Edwards R, Chapman H, Young P, Roberts S, et al.
J Pharmacol Exp Ther
. 1991 Nov;
259(2):643-52.
PMID: 1682482
SK&F 104856 (2-vinyl-7-chloro-3,4,5,6-tetrahydro-4-methyl-thieno[4,3,2ef][3] benzazepine) shows a similar selectivity profile to the previously reported alpha adrenoceptor antagonist, SK&F 104078 (6-chloro-9-[(3-methyl-2-butenyl)oxy]-3-methyl-1H-2,3,4,5-tetrahydro-3- benzazepine), having the ability to block alpha-1 and postjunctional alpha-2 adrenoceptors,...
2.
Daly R, Sulpizio A, Levitt B, DeMarinis R, Regan J, Ruffolo Jr R, et al.
J Pharmacol Exp Ther
. 1988 Oct;
247(1):122-8.
PMID: 2902209
A series of alpha adrenoceptor antagonists, including both reference compounds and the novel benzazepine antagonists, SK&F 86466 (6-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine) and two of its 9-substituted derivatives, SK&F 101253 and SK&F 104078, were...
3.
Gombar C, DeMarinis R, Wise M, Mico B
Drug Metab Dispos
. 1988 May;
16(3):367-72.
PMID: 2900727
To aid in the effort to discover novel agents for the treatment of cardiovascular disease, the relationships between pharmacokinetic parameters in the rat and lipophilicity and basicity were studied for...
4.
Ruffolo Jr R, Sulpizio A, Nichols A, DeMarinis R, Hieble J
Naunyn Schmiedebergs Arch Pharmacol
. 1987 Oct;
336(4):415-8.
PMID: 2893296
Most alpha 2-adrenoceptor antagonists do not discriminate between pre- and postjunctional alpha 2-adrenoceptors, and this has led to the commonly held belief that pre- and postjunctional alpha 2-adrenoceptors may represent...
5.
Ross S, Franz R, Gallagher Jr G, Brenner M, Wilson J, DeMarinis R, et al.
J Med Chem
. 1987 Jan;
30(1):35-40.
PMID: 3806602
The N-allyl derivative (SK&F 85174) of 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol (SK&F 82526) retains the DA-1 agonist potency of the latter compound but unlike the parent also shows substantial DA-2 agonist activity. In a...
6.
Hieble J, Owen D, Harvey C, Blumberg A, Valocik R, DeMarinis R
Clin Exp Hypertens A
. 1987 Jan;
9(5-6):889-912.
PMID: 2887313
The availability of highly selective dopamine receptor agonists has allowed the characterization of the role of DA1 and DA2 receptors in the cardiovascular system. Fenoldopam (SK&F 82526) is a potent...
7.
Hieble J, Sulpizio A, Nichols A, DeMarinis R, PFEIFFER F, Lavanchy P, et al.
J Hypertens Suppl
. 1986 Dec;
4(6):S189-92.
PMID: 2886570
It is now recognized that two post-junctional alpha-adrenoceptors mediate vascular constriction. The vascular alpha 2-adrenoceptors seem to be particularly sensitive to circulating catecholamine levels, in contrast to the alpha 1-adrenoceptors,...
8.
SWAGZDIS J, Wittendorf R, DeMarinis R, Mico B
J Pharm Sci
. 1986 Oct;
75(10):925-8.
PMID: 3795020
The absorption, protein binding, blood-to-plasma ratio, renal excretion, and pharmacokinetics of the dopamine-2 agonists (D2-agonists) 4-(2-di-n-propylaminoethyl)-7-hydroxy-2-(3H)-indolone (1), N-(2'-hydroxy-5'-[N,N-di-n-propylaminoethylphenyl])methanesulfonamide (2), and 4-(2-di-n-propylaminoethyl)-2-(3H)-indolone (3) were examined in dogs and rats. On the...
9.
Photoaffinity labeling of human platelet and rabbit kidney alpha 2-adrenoceptors with [3H]SKF 102229
Regan J, Raymond J, Lefkowitz R, DeMarinis R
Biochem Biophys Res Commun
. 1986 Jun;
137(2):606-13.
PMID: 3015124
A newly developed alpha 2-adrenergic photoaffinity ligand, 3-methyl-6-chloro-9-azido-1H-2,3,4,5-tetrahydro-3-benzazepine (SKF 102229), has been radiolabeled with tritium to a specific activity of approximately 80 Ci/mmol. Using membranes prepared from human platelets and...
10.
DeMarinis R, Gallagher Jr G, Hall R, Franz R, Webster C, Huffman W, et al.
J Med Chem
. 1986 Jun;
29(6):939-47.
PMID: 3712384
A series of (beta-aminoethyl)indolones and related compounds was synthesized and evaluated in vitro as peripheral prejunctional dopaminergic agonists in the field-stimulated isolated perfused rabbit ear artery. 4-[2-(Di-n-propylamino)ethyl]-7-hydroxy-2(3H)-indolone was the most...