Alpha 2.0
Login Register
» Authors » W Lilienblum

W Lilienblum

Explore the profile of W Lilienblum including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 23
Citations 240
Followers 0
Related Specialties
Pharmacology
Biochemistry
Toxicology
Top 10 Co-Authors
K W Bock
H PFEIL
G Fischer
G Schirmer
H Schweinfurth
H Foth
R Kahl
J G Hengstler
P-J Kramer
K-M Wollin
Published In
Biochem Pharmacol
Adv Exp Med Biol
Arch Toxicol
Mol Pharmacol
Chem Biol Interact
Affiliations
Soon will be listed here.
Recent Articles
1.
Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A
Hengstler J, Foth H, Gebel T, Kramer P, Lilienblum W, Schweinfurth H, et al.
Crit Rev Toxicol . 2011 Mar; 41(4):263-91. PMID: 21438738
Despite the fact that more than 5000 safety-related studies have been published on bisphenol A (BPA), there seems to be no resolution of the apparently deadlocked controversy as to whether...
2.
Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH)
Lilienblum W, Dekant W, Foth H, Gebel T, Hengstler J, Kahl R, et al.
Arch Toxicol . 2008 Mar; 82(4):211-36. PMID: 18322675
During the last two decades, substantial efforts have been made towards the development and international acceptance of alternative methods to safety studies using laboratory animals. In the EU, challenging timelines...
3.
The REACH concept and its impact on toxicological sciences
Hengstler J, Foth H, Kahl R, Kramer P, Lilienblum W, Schulz T, et al.
Toxicology . 2006 Mar; 220(2-3):232-9. PMID: 16555380
No abstract available.
4.
Regioselectivity of rat liver microsomal UDP-glucuronosyltransferase activities toward phenols of benzo(a)pyrene and dibenz(a,h)anthracene
Lilienblum W, Platt K, Schirmer G, Oesch F, Bock K
Mol Pharmacol . 1987 Jul; 32(1):173-7. PMID: 3110592
Inducibility of rat liver microsomal UDP-glucuronosyltransferase was investigated with regard to the substrate structure using 3-, 6-, 7-, 8-, and 9-hydroxybenzo(a)pyrene, all seven phenols of dibenz(a,h)anthracene, 3-hydroxybenz(a)anthracene, and 3-hydroxyfluoranthene as...
5.
The role of conjugation reactions in detoxication
Bock K, Lilienblum W, Fischer G, Schirmer G
Arch Toxicol . 1987 Jan; 60(1-3):22-9. PMID: 3304211
The role of conjugating enzymes is best understood by looking at the interaction between phase I (mostly cytochromes P-450) and phase II (conjugation) enzymes of drug metabolism. A balance between...
6.
Induction and inhibition of conjugating enzymes with emphasis on UDP-glucuronyltransferases
Bock K, Lilienblum W, Fischer G, Schirmer G
Pharmacol Ther . 1987 Jan; 33(1):23-7. PMID: 3114774
No abstract available.
7.
Immunohistochemical differentiation of gamma-glutamyltranspeptidase in focal lesions and in zone I of rat liver after treatment with chemical carcinogens
Fischer G, Lilienblum W, Ullrich D, Bock K
Carcinogenesis . 1986 Sep; 7(9):1405-10. PMID: 2874897
gamma-Glutamyltranspeptidase (gamma-GT) is known to be increased in putative pre-neoplastic foci but also in the periportal zone I of rat liver under a variety of circumstances not directly related to...
8.
Induction of UDP-glucuronyltransferase and arylhydrocarbon hydroxylase activity in mouse skin and in normal and transformed skin cells in culture
Lilienblum W, IRMSCHER G, Fusenig N, Bock K
Biochem Pharmacol . 1986 May; 35(9):1517-20. PMID: 3085679
Methods have been developed which allow quantitative determination of UDP-glucuronyltransferase (UDPGT) and arylhydrocarbon hydroxylase (AHH) activities in unfractionated mouse skin. These methods were used for comparative studies of basal and...
9.
UDP-glucuronyltransferases and their toxicological significance
Bock K, Fischer G, Lilienblum W, Schirmer G
Adv Exp Med Biol . 1986 Jan; 197:171-84. PMID: 3094334
No abstract available.
10.
Protection against toxic redox cycles between benzo(a)pyrene-3,6-quinone and its quinol by 3-methylcholanthrene-inducible formation of the quinol mono- and diglucuronide
Lilienblum W, Bock K
Mol Pharmacol . 1985 Apr; 27(4):451-8. PMID: 3982390
Cytotoxic effects of quinones are thought to be mediated by redox cycles between quinones and quinols whereby reactive oxygen species are generated. The role of glucuronidation in preventing these toxic...