W Leupin
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Explore the profile of W Leupin including associated specialties, affiliations and a list of published articles.
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35
Citations
468
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Recent Articles
1.
Ji Y, Bur D, Hasler W, Runtz Schmitt V, Dorn A, Bailly C, et al.
Bioorg Med Chem
. 2001 Oct;
9(11):2905-19.
PMID: 11597472
Two tris-benzimidazole derivatives have been designed and synthesized based on the known structures of the bis-benzimidazole stain Hoechst 33258 complexed to short oligonucleotide duplexes derived from single crystal X-ray studies...
2.
Ridley R, Matile H, JAQUET C, Dorn A, HOFHEINZ W, Leupin W, et al.
Antimicrob Agents Chemother
. 1997 Mar;
41(3):677-86.
PMID: 9056013
The S,S enantiomer of the bisquinoline trans-N1,N2-bis(7-chloroquinolin-4-yl)cyclohexane-1,2-diamine, Ro 47-7737, is significantly more potent against chloroquine-resistant Plasmodium falciparum than the R,R enantiomer and the previously described racemate. Both the enantiomers and...
3.
Clark G, Squire C, Gray E, Leupin W, Neidle S
Nucleic Acids Res
. 1996 Dec;
24(24):4882-9.
PMID: 9017011
An analogue of the DNA binding compound Hoechst 33258, which has the para hydroxyl group altered to be at the meta position, together with the replacement of one benzimidazole group...
4.
Clark G, Gray E, Neidle S, Li Y, Leupin W
Biochemistry
. 1996 Oct;
35(43):13745-52.
PMID: 8901516
The crystal structure is reported of a tris(benzimidazole) analogue of the minor-groove drug Hoechst 33258 bound to the sequence d(CGCAAATTTGCG)2. The structure has been refined to an R factor of...
5.
Jacobson A, Leupin W, Liepinsh E, Otting F
Nucleic Acids Res
. 1996 Aug;
24(15):2911-8.
PMID: 8760873
The hydration in the minor groove of double stranded DNA fragments containing the sequences 5'-dTTAAT, 5'-dTTAAC, 5'-dTTAAA and 5'-dTTAAG was investigated by studying the decanucleotide duplex d(GCATTAATGC)2 and the singly...
6.
Rydzewski J, Leupin W, Chazin W
Nucleic Acids Res
. 1996 Apr;
24(7):1287-93.
PMID: 8614632
A complex between d(GGGAAAAACGG).d(CCGTTTTTCCC) and the minor groove binding drug SN-6999 has been studied by 1H nuclear magnetic resonance spectroscopy. The drug is found to bind in the d(A)5 tract,...
7.
Altmann S, Labhardt A, Bur D, Lehmann C, Bannwarth W, Billeter M, et al.
Nucleic Acids Res
. 1995 Dec;
23(23):4827-35.
PMID: 8532525
Molecular modelling studies resulted in the design of a variety of non-nucleotidic covalent linkers to bridge the 3'-end of the (+)-strand and the 5'-end of the (-)-strand in DNA duplexes....
8.
Liepinsh E, Leupin W, Otting G
Nucleic Acids Res
. 1994 Jun;
22(12):2249-54.
PMID: 8036152
The residence times of the hydration water molecules near the base protons of d-(GTGGAATTCCAC)2 and d-(GTGGTTAACCAC)2 were investigated by nuclear magnetic resonance (NMR) spectroscopy. Nuclear Overhauser effects (NOE) were observed...
9.
Dorn A, Affolter M, Gehring W, Leupin W
Pharmacol Ther
. 1994 Jan;
61(1-2):155-84.
PMID: 7938169
Homeobox genes encode transcriptional regulators found in all organisms ranging from yeast to humans. In Drosophila, a specific class of homeobox genes, the homeotic genes, specifies the identity of certain...
10.
Fede A, Billeter M, Leupin W, Wuthrich K
Structure
. 1993 Nov;
1(3):177-86.
PMID: 16100952
Background: The chromosomal stain, Hoechst 33258, binds to the minor groove of the DNA double helix and specifically recognizes a run of four A-T base pairs. Extensive biochemical and biophysical...