W Ewan Hume
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Explore the profile of W Ewan Hume including associated specialties, affiliations and a list of published articles.
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8
Citations
60
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Recent Articles
1.
Shingaki T, Hume W, Takashima T, Katayama Y, Okauchi T, Hayashinaka E, et al.
Pharm Res
. 2015 Feb;
32(8):2538-47.
PMID: 25715695
Purpose: To evaluate the function of multidrug and toxin extrusion proteins (MATEs) using (11)C-labeled metformin ([(11)C]metformin) by positron emission tomography (PET). Methods: PET was performed by intravenous bolus injection of...
2.
Hume W, Shingaki T, Takashima T, Hashizume Y, Okauchi T, Katayama Y, et al.
Bioorg Med Chem
. 2013 Nov;
21(24):7584-90.
PMID: 24238901
In order to develop a new positron emission tomography (PET) probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1), (11)C-labelled metformin was synthesized and...
3.
Sugaru E, Nakagawa T, Ono-Kishino M, Nagamine J, Tokunaga T, Kitoh M, et al.
Nephron Exp Nephrol
. 2006 Dec;
105(2):e45-52.
PMID: 17139189
Background/aims: Diabetic nephropathy is the main cause of end-stage renal disease. Previously we have demonstrated that SMP-534 (an antifibrotic agent) prevents the development of diabetic nephropathy in db/db mouse and...
4.
Nagamine J, Kawamura T, Tokunaga T, Hume W, Nagata R, Nakagawa T, et al.
Comb Chem High Throughput Screen
. 2006 Mar;
9(3):187-96.
PMID: 16533152
Hypothalamic hormones physiologically regulate pulsatile release of growth hormone (GH) from the anterior pituitary gland. Since the discovery of these hormones in the 1970s, several new chemically synthesized peptidyl and...
5.
Sugaru E, Nakagawa T, Ono-Kishino M, Nagamine J, Tokunaga T, Kitoh M, et al.
Am J Nephrol
. 2006 Mar;
26(1):50-8.
PMID: 16508247
Background/aims: Diabetic nephropathy is now the most common cause of end-stage renal disease. It is also clear that the current therapy, angiotensin II blockage, cannot prevent the progression of diabetic...
6.
Sugaru E, Nakagawa T, Ono-Kishino M, Nagamine J, Tokunaga T, Kitoh M, et al.
Am J Physiol Renal Physiol
. 2005 Nov;
290(4):F813-20.
PMID: 16278277
Diabetic nephropathy is currently the most common cause of end-stage renal disease. Diabetic nephropathy patients, whether insulin dependent or not, develop fibrotic changes in glomeruli that manifest as overt nephropathy....
7.
Sugaru E, Sakai M, Horigome K, Tokunaga T, Kitoh M, Hume W, et al.
Am J Physiol Renal Physiol
. 2005 May;
289(5):F998-1004.
PMID: 15900023
Transforming growth factor-beta (TGF-beta) is a potent fibrotic factor responsible for the synthesis of extracellular matrix (ECM) and is implicated as the major determinant in pathogenesis of chronic fibroses, including...
8.
Tokunaga T, Hume W, Nagamine J, Kawamura T, Taiji M, Nagata R
Bioorg Med Chem Lett
. 2005 Mar;
15(7):1789-92.
PMID: 15780607
A series of substituted oxindole derivatives of SM-130686 was synthesized and evaluated as ghrelin receptor agonists. Modification of the substituents on the C3-aromatic part of the oxindole led to compounds...