W E Holmes
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Explore the profile of W E Holmes including associated specialties, affiliations and a list of published articles.
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24
Citations
1171
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Recent Articles
11.
Holmes W, Sliwkowski M, Akita R, Henzel W, Lee J, Park J, et al.
Science
. 1992 May;
256(5060):1205-10.
PMID: 1350381
The proto-oncogene designated erbB2 or HER2 encodes a 185-kilodalton transmembrane tyrosine kinase (p185erbB2), whose overexpression has been correlated with a poor prognosis in several human malignancies. A 45-kilodalton protein heregulin-alpha...
12.
Holmes W, Lee J, Kuang W, Rice G, Wood W
Science
. 1991 Sep;
253(5025):1278-80.
PMID: 1840701
Interleukin-8 (IL-8) is a member of a family of pro-inflammatory cytokines. Although the best characterized activities of IL-8 include the chemoattraction and activation of neutrophils, other members of this family...
13.
Hudziak R, Lewis G, Holmes W, Ullrich A, Shepard H
Cell Growth Differ
. 1990 Mar;
1(3):129-34.
PMID: 2078501
Alterations in the structure and expression of protein tyrosine kinases are associated with cellular transformation and tumorigenicity. These enzymes may contribute to tumor progression by interfering with host mechanisms of...
14.
Lijnen H, Nelles L, Holmes W, Collen D
J Biol Chem
. 1988 Apr;
263(12):5594-8.
PMID: 2965704
The cDNA encoding a low Mr derivative (residues 144-411) of human single-chain urokinase-type plasminogen activator was cloned, the recombinant low Mr single-chain urokinase-type plasminogen activator (rscu-PA-32k) was expressed in Chinese...
15.
Lijnen H, Van Hoef B, Nelles L, Holmes W, Collen D
Eur J Biochem
. 1988 Feb;
172(1):185-8.
PMID: 2894309
Recombinant single-chain urokinase-type plasminogen activator (rscu-PA), in which the plasmin-sensitive peptide bond Lys158-Ile159 is destroyed by site-specific mutagenesis of Lys158 to Glu (rscu-PA-Glu158), is quantitatively converted to two-chain urokinase-type plasminogen...
16.
Holmes W, Lijnen H, Nelles L, Kluft C, Nieuwenhuis H, Rijken D, et al.
Science
. 1987 Oct;
238(4824):209-11.
PMID: 2958938
An abnormal alpha 2-antiplasmin that is associated with a serious bleeding tendency has been found in a Dutch family and is referred to as alpha 2-antiplasmin Enschede. This abnormal alpha...
17.
Holmes W, Lijnen H, Collen D
Biochemistry
. 1987 Aug;
26(16):5133-40.
PMID: 2444252
Human alpha 2-antiplasmin (alpha 2AP) has been expressed in Chinese hamster ovary cells and purified from conditioned media. The recombinant protein (r alpha 2AP) is immunologically identical with natural alpha...
18.
Nelles L, Lijnen H, Collen D, Holmes W
J Biol Chem
. 1987 Aug;
262(22):10855-62.
PMID: 2956260
A hybrid human cDNA was constructed by splicing of a cDNA fragment of tissue-type plasminogen activator (t-PA), encoding 5'-untranslated, the pre-pro region and amino acids Ser1-Thr263, with a cDNA fragment...
19.
Lijnen H, Holmes W, Van Hoef B, Wiman B, Rodriguez H, Collen D
Eur J Biochem
. 1987 Aug;
166(3):565-74.
PMID: 2440681
The amino-acid sequence of human alpha 2-antiplasmin was determined by Edman degradation of peptides purified from CNBr, tryptic and chymotryptic digests. Of the total sequence of 452 amino acids of...
20.
Nelles L, Lijnen H, Collen D, Holmes W
J Biol Chem
. 1987 Apr;
262(12):5682-9.
PMID: 3106341
The cDNA encoding full-length single chain urokinase-type plasminogen activator (scu-PA) was cloned and sequenced, and the recombinant scu-PA (rscu-PA) was expressed in Chinese hamster ovary cells. Two mutants, constructed by...