W E DeWolf Jr
Overview
Explore the profile of W E DeWolf Jr including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
36
Citations
381
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Head M, Ryan M, Lee D, Feng Y, Janson C, Concha N, et al.
J Comput Aided Mol Des
. 2002 Aug;
15(12):1105-17.
PMID: 12160093
Structure-based design of a combinatorial array was carried out in order to identify non-peptidic thiomethylketone inhibitors of caspases 3 and 8. Five compounds from the designed array were active against...
2.
Wong V, Keller P, Nuttall M, Kikly K, DeWolf Jr W, Lee D, et al.
Eur J Pharmacol
. 2002 Jan;
433(2-3):135-40.
PMID: 11755144
In the present study, we have used an in vitro model of apoptosis using primary human renal proximal tubular epithelial (RPTE) cells to investigate the mechanisms involved in renal cell...
3.
Seefeld M, Miller W, Newlander K, BURGESS W, Payne D, Rittenhouse S, et al.
Bioorg Med Chem Lett
. 2001 Aug;
11(17):2241-4.
PMID: 11527706
An SAR study of a screening lead has led to the identification of 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as inhibitors of Staphylococcus aureus enoyl acyl carrier protein reductase (FabI).
4.
Van Aller G, Greenwood R, Nicholas R, Keller P, DeWolf Jr W, Fan F, et al.
J Antimicrob Chemother
. 2001 Jun;
48(1):1-6.
PMID: 11418506
Triclosan, a widely used antibacterial agent, possesses potent activity against Staphylococcus aureus. This study reports on an investigation of the antibacterial target of triclosan in this pathogen. A strain of...
5.
Lee D, Long S, Murray J, Adams J, Nuttall M, Nadeau D, et al.
J Med Chem
. 2001 Jun;
44(12):2015-26.
PMID: 11384246
5-Dialkylaminosulfonylisatins have been identified as potent, nonpeptide inhibitors of caspases 3 and 7. The most active compound within this series (34) inhibited caspases 3 and 7 in the 2-6 nM...
6.
Nuttall M, Nadeau D, Fisher P, Wang F, Keller P, DeWolf Jr W, et al.
J Orthop Res
. 2000 Aug;
18(3):356-63.
PMID: 10937621
Apoptosis was induced in a human chondrocyte cell line, T/C 28a4, by treatment with various stimuli, including camptothecin, tumor necrosis factor-alpha, staurosporine, okadaic acid, and reduced serum conditions. All stimuli...
7.
Lee D, Long S, Adams J, Chan G, Vaidya K, Francis T, et al.
J Biol Chem
. 2000 May;
275(21):16007-14.
PMID: 10821855
Caspases have been strongly implicated to play an essential role in apoptosis. A critical question regarding the role(s) of these proteases is whether selective inhibition of an effector caspase(s) will...
8.
Ali S, Wong V, Kikly K, Fredrickson T, Keller P, DeWolf Jr W, et al.
Am J Physiol Regul Integr Comp Physiol
. 2000 Mar;
278(3):R763-9.
PMID: 10712299
Polycystic kidney disease (PKD) is characterized by the development of large renal cysts and progressive loss of renal function. Although the cause of the development of renal cysts is unknown,...
9.
Lee D, Adams J, Brandt M, DeWolf Jr W, Keller P, Levy M
Bioorg Med Chem Lett
. 1999 Jul;
9(12):1667-72.
PMID: 10397497
An efficient strategy for the synthesis of a tetrapeptidyl substrate combinatorial array directed toward the caspases is described. Testing of this array with caspases 1 and 4 gave substrate hydrolytic...
10.
Yue T, Ni J, Romanic A, Gu J, Keller P, Wang C, et al.
J Biol Chem
. 1999 Jan;
274(3):1479-86.
PMID: 9880523
TL1 is a recently discovered novel member of the tumor necrosis factor (TNF) cytokine family. TL1 is abundantly expressed in endothelial cells, but its function is not known. The present...