W Alexander Stinson
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Explore the profile of W Alexander Stinson including associated specialties, affiliations and a list of published articles.
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7
Citations
122
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Recent Articles
1.
Poddar S, Chauvin S, Archer C, Qian W, Castillo-Badillo J, Yin X, et al.
Cell
. 2025 Feb;
PMID: 39947179
Stimulator of interferon genes (STING) transmits signals downstream of the cytosolic DNA sensor cyclic guanosine monophosphate-AMP synthase (cGAS), leading to transcriptional upregulation of cytokines. However, components of the STING signaling...
2.
Chauvin S, Ando S, Holley J, Sugie A, Zhao F, Poddar S, et al.
Nat Commun
. 2024 Jun;
15(1):4696.
PMID: 38824133
Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the brain, retina, liver, and kidney. Based on the DNA damage theory of aging, we reasoned that genomic...
3.
Chauvin S, Stinson W, Platt D, Poddar S, Miner J
J Biol Chem
. 2023 May;
299(7):104866.
PMID: 37247757
Stimulator of interferon genes (STING) is a sensor of cyclic dinucleotides including cyclic GMP-AMP, which is produced by cyclic GMP-AMP synthase (cGAS) in response to cytosolic DNA. The cGAS-STING signaling...
4.
Stinson W, Miner C, Zhao F, Lundgren A, Poddar S, Miner J
JCI Insight
. 2022 Sep;
7(17).
PMID: 36073546
STING gain-of-function mutations cause STING-associated vasculopathy with onset in infancy (SAVI) in humans, a disease characterized by spontaneous lung inflammation and fibrosis. Mice with STING gain-of-function mutations (SAVI mice) develop...
5.
Platt D, Lawrence D, Rodgers R, Schriefer L, Qian W, Miner C, et al.
Cell Rep
. 2021 May;
35(6):109113.
PMID: 33979608
STING modulates immunity by responding to bacterial and endogenous cyclic dinucleotides (CDNs). Humans and mice with STING gain-of-function mutations develop a syndrome known as STING-associated vasculopathy with onset in infancy...
6.
Luksch H, Stinson W, Platt D, Qian W, Kalugotla G, Miner C, et al.
J Allergy Clin Immunol
. 2019 Feb;
144(1):254-266.e8.
PMID: 30772497
Background: Monogenic interferonopathies are thought to be mediated by type I interferon. For example, a gain-of-function mutation in stimulator of interferon genes (STING; N153S) upregulates type I interferon-stimulated genes and...
7.
OBrien M, Shu Q, Stinson W, Tsou P, Ruth J, Isozaki T, et al.
Arthritis Res Ther
. 2018 Feb;
20(1):31.
PMID: 29433546
Background: Galectin-9 (Gal-9) is a mammalian lectin secreted by endothelial cells that is highly expressed in rheumatoid arthritis synovial tissues and synovial fluid. Roles have been proposed for galectins in...
8.
Du Y, Tong Y, Mei W, Jia J, Niu M, Cao W, et al.
Adv Healthc Mater
. 2016 Oct;
5(22):2911-2921.
PMID: 27709830
Peptide-based therapy, such as modified peptides, has attracted increased attention. IL-17 is a promising therapeutic target for autoimmune diseases, and levels of circulating bioactive IL-17 are associated with rheumatoid arthritis...