Regulation of CGAS and STING Signaling During Inflammation and Infection

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2023 May 29

PMID 37247757

Authors

Samuel D Chauvin

W Alexander Stinson

Derek J Platt

Subhajit Poddar

Jonathan J Miner

Affiliations

Soon will be listed here.

Abstract

Stimulator of interferon genes (STING) is a sensor of cyclic dinucleotides including cyclic GMP-AMP, which is produced by cyclic GMP-AMP synthase (cGAS) in response to cytosolic DNA. The cGAS-STING signaling pathway regulates both innate and adaptive immune responses, as well as fundamental cellular functions such as autophagy, senescence, and apoptosis. Mutations leading to constitutive activation of STING cause devastating human diseases. Thus, the cGAS-STING pathway is of great interest because of its role in diverse cellular processes and because of the potential therapeutic implications of targeting cGAS and STING. Here, we review molecular and cellular mechanisms of STING signaling, and we propose a framework for understanding the immunological and other cellular functions of STING in the context of disease.

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