Vojtech Dvorak
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Explore the profile of Vojtech Dvorak including associated specialties, affiliations and a list of published articles.
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8
Citations
87
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Recent Articles
1.
Wolf G, Craigon C, Teoh S, Essletzbichler P, Onstein S, Cassidy D, et al.
Cell Chem Biol
. 2025 Jan;
32(2):291-306.e6.
PMID: 39755121
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting "undruggable"...
2.
Digles D, Ingles-Prieto A, Dvorak V, Mocking T, Goldmann U, Garofoli A, et al.
Front Pharmacol
. 2024 Jul;
15:1401599.
PMID: 39050757
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with...
3.
Boeszoermenyi A, Bernaleau L, Chen X, Kartnig F, Xie M, Zhang H, et al.
Nat Commun
. 2023 Oct;
14(1):6626.
PMID: 37863876
Dysregulation of pathogen-recognition pathways of the innate immune system is associated with multiple autoimmune disorders. Due to the intricacies of the molecular network involved, the identification of pathway- and disease-specific...
4.
Dvorak V, Superti-Furga G
Expert Opin Drug Discov
. 2023 Aug;
18(10):1099-1115.
PMID: 37563933
Introduction: Solute carriers (SLCs) represent the largest group of membrane transporters in the human genome. They play a central role in controlling the compartmentalization of metabolism and most of this...
5.
Dvorak V, Casiraghi A, Colas C, Koren A, Tomek T, Offensperger F, et al.
Cell Chem Biol
. 2023 Jul;
30(8):953-964.e9.
PMID: 37516113
Despite being considered druggable and attractive therapeutic targets, most of the solute carrier (SLC) membrane transporters remain pharmacologically underexploited. One of the reasons for this is a lack of reliable...
6.
Dvorak V, Wiedmer T, Ingles-Prieto A, Altermatt P, Batoulis H, Barenz F, et al.
Front Pharmacol
. 2021 Aug;
12:722889.
PMID: 34447313
The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and druggable targets, the majority of SLCs remains understudied....
7.
Bensimon A, Pizzagalli M, Kartnig F, Dvorak V, Essletzbichler P, Winter G, et al.
Cell Chem Biol
. 2020 May;
27(6):728-739.e9.
PMID: 32386596
With more than 450 members, the solute carrier (SLC) group of proteins represents the largest class of transporters encoded in the human genome. Their several-pass transmembrane domain structure and hydrophobicity...
8.
Lacina P, Dvorak V, Vodickova E, Barson P, Kalivoda J, Goold S
Water Environ Res
. 2015 Oct;
87(4):326-33.
PMID: 26462077
In this paper, the authors present the pilot in situ application of nano zero-valent iron (nZVI) for effective remediation of groundwater in an industrial area contaminated by chlorinated ethylenes (CEs),...