Vladimir R Babaev
Overview
Explore the profile of Vladimir R Babaev including associated specialties, affiliations and a list of published articles.
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36
Citations
2086
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Recent Articles
1.
Guillermier C, Doherty S, Whitney A, Babaev V, Linton M, Steinhauser M, et al.
JCI Insight
. 2019 Jun;
4(11).
PMID: 31167964
Atherosclerotic plaques feature local proliferation of leukocytes and vascular smooth muscle cells (VSMCs) and changes in cellular metabolism. Yet the relationship between glucose utilization and proliferation has been technically impossible...
2.
Linton M, Moslehi J, Babaev V
Int J Mol Sci
. 2019 Jun;
20(11).
PMID: 31159424
The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of macrophages, which may impact the development of atherosclerosis. Changes in Akt isoforms or modulation of the...
3.
Babaev V, Ding L, Zhang Y, May J, Ramsey S, Vickers K, et al.
Arterioscler Thromb Vasc Biol
. 2018 Dec;
39(2):156-169.
PMID: 30567482
Objective- Macrophages express 3 Akt (protein kinase B) isoforms, Akt1, Akt2, and Akt3, which display isoform-specific functions but may be redundant in terms of Akt survival signaling. We hypothesize that...
4.
Babaev V, Huang J, Ding L, Zhang Y, May J, Linton M
Front Immunol
. 2018 Mar;
9:215.
PMID: 29487597
Background: Rictor is an essential component of mammalian target of rapamycin (mTOR) complex 2 (mTORC2), a conserved serine/threonine kinase that may play a role in cell proliferation, survival and innate...
5.
Linton M, Babaev V, Huang J, Linton E, Tao H, Yancey P
Circ J
. 2016 Oct;
80(11):2259-2268.
PMID: 27725526
Macrophage apoptosis and the ability of macrophages to clean up dead cells, a process called efferocytosis, are crucial determinants of atherosclerosis lesion progression and plaque stability. Environmental stressors initiate endoplasmic...
6.
Babaev V, Yeung M, Erbay E, Ding L, Zhang Y, May J, et al.
Arterioscler Thromb Vasc Biol
. 2016 Apr;
36(6):1122-31.
PMID: 27102962
Objective: The c-Jun NH2-terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic signaling. Macrophages express 2 JNK isoforms, JNK1 and JNK2,...
7.
Babaev V, Ding L, Zhang Y, May J, Lin P, Fazio S, et al.
Arterioscler Thromb Vasc Biol
. 2016 Feb;
36(4):598-607.
PMID: 26848161
Objective: The IκB kinase (IKK) is an enzyme complex that initiates the nuclear factor κB transcription factor cascade, which is important in regulating multiple cellular responses. IKKα is directly associated...
8.
Tao H, Yancey P, Babaev V, Blakemore J, Zhang Y, Ding L, et al.
J Lipid Res
. 2015 Jun;
56(8):1449-60.
PMID: 26059978
Macrophage apoptosis and efferocytosis are key determinants of atherosclerotic plaque inflammation and necrosis. Bone marrow transplantation studies in ApoE- and LDLR-deficient mice revealed that hematopoietic scavenger receptor class B type...
9.
Segedy A, Pyle A, Li B, Zhang Y, Babaev V, Jat P, et al.
Arterioscler Thromb Vasc Biol
. 2014 Oct;
34(12):2527-36.
PMID: 25278290
Objective: Atherosclerosis is the primary driver of cardiovascular disease, the leading cause of death worldwide. Identification of naturally occurring atheroprotective genes has become a major goal for the development of...
10.
Babaev V, Hebron K, Wiese C, Toth C, Ding L, Zhang Y, et al.
J Lipid Res
. 2014 Sep;
55(11):2296-308.
PMID: 25240046
Macrophages play crucial roles in the formation of atherosclerotic lesions. Akt, a serine/threonine protein kinase B, is vital for cell proliferation, migration, and survival. Macrophages express three Akt isoforms, Akt1,...