Vladimir I Klichko
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Explore the profile of Vladimir I Klichko including associated specialties, affiliations and a list of published articles.
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19
Citations
371
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Recent Articles
1.
Odnokoz O, Earland N, Badinloo M, Klichko V, Benes J, Orr W, et al.
Antioxidants (Basel)
. 2023 Aug;
12(8).
PMID: 37627611
Aberrant immune responses and chronic inflammation can impose significant health risks and promote premature aging. Pro-inflammatory responses are largely mediated via reactive oxygen species (ROS) and reduction-oxidation reactions. A pivotal...
2.
McGinnis A, Klichko V, Orr W, Radyuk S
Antioxidants (Basel)
. 2021 Apr;
10(4).
PMID: 33920774
The catalytic activity of peroxiredoxins (Prx) is determined by the conserved peroxidatic cysteine (Cys), which reacts with peroxides to form sulfenic acid (Cys-SOH). Under conditions of oxidative stress, Cys is...
3.
Odnokoz O, Nakatsuka K, Wright C, Castellanos J, Klichko V, Kretzschmar D, et al.
Front Cell Dev Biol
. 2021 Feb;
9:613036.
PMID: 33585478
Mitochondrial dysfunction often leads to neurodegeneration and is considered one of the main causes of neurological disorders, such as Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and other age-related diseases....
4.
Klichko V, Safonov V, Safonov M, Radyuk S
Heliyon
. 2019 Jun;
5(5):e01679.
PMID: 31193183
Recently, molecular hydrogen (H) has become known as a new class of antioxidants and redox-modulating interventions. Effects of H have been documented for many acute and chronic pathological conditions. The...
5.
Badinloo M, Nguyen E, Suh W, Alzahrani F, Castellanos J, Klichko V, et al.
Arch Insect Biochem Physiol
. 2018 Apr;
98(4):e21464.
PMID: 29637607
The innate immune response tends to become hyperactive and proinflammatory in older organisms. We investigated connections between activity of the immune-related genes and aging using the Drosophila model. A hallmark...
6.
Odnokoz O, Nakatsuka K, Klichko V, Nguyen J, Solis L, Ostling K, et al.
Biochim Biophys Acta Mol Basis Dis
. 2016 Nov;
1863(1):68-80.
PMID: 27770625
Previously, we have shown that flies under-expressing the two mitochondrial peroxiredoxins (Prxs), dPrx3 and dPrx5, display increases in tissue-specific apoptosis and dramatically shortened life span, associated with a redox crisis,...
7.
Klichko V, Orr W, Radyuk S
Biochim Biophys Acta
. 2015 Dec;
1862(2):265-73.
PMID: 26689888
In prior studies, we determined that the moderate overexpression of the Drosophila endoplasmic reticulum (ER)-localized peroxiredoxin (Prx), dPrx4, reduced oxidative damage and conferred beneficial effects on life span, while a...
8.
Klichko V, Chow E, Kotwica-Rolinska J, Orr W, Giebultowicz J, Radyuk S
Front Genet
. 2015 Mar;
6:83.
PMID: 25806044
Circadian coordination of metabolism, physiology, and neural functions contributes to healthy aging and disease prevention. Clock genes govern the daily rhythmic expression of target genes whose activities underlie such broad...
9.
Radyuk S, Klichko V, Michalak K, Orr W
FASEB J
. 2012 Dec;
27(4):1426-38.
PMID: 23271054
Peroxiredoxin 4 (Prx4) has been implicated in a wide variety of biological processes, including development, progression of cancer, inflammation, and antioxidant function. The purpose of this study was to provide...
10.
Beaver L, Klichko V, Chow E, Kotwica-Rolinska J, Williamson M, Orr W, et al.
PLoS One
. 2012 Dec;
7(11):e50454.
PMID: 23226288
Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels of the major endogenous antioxidant, glutathione (GSH), but the molecular...