Vladimir I Klichko
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Explore the profile of Vladimir I Klichko including associated specialties, affiliations and a list of published articles.
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19
Citations
371
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Recent Articles
11.
Radyuk S, Gambini J, Borras C, Serna E, Klichko V, Vina J, et al.
Mech Ageing Dev
. 2012 May;
133(6):401-13.
PMID: 22579812
In our prior studies (Orr et al., 2005) we achieved a 30-50% increase in the life span of Drosophila by manipulating glutathione (GSH) production in neuronal tissues, through over-expression of...
12.
Radyuk S, Rebrin I, Klichko V, Sohal B, Michalak K, Benes J, et al.
Free Radic Biol Med
. 2010 Sep;
49(12):1892-902.
PMID: 20869434
Drosophila mitochondria contain two peroxidases, peroxiredoxin 3 (dPrx3) and peroxiredoxin 5 (dPrx5), which together constitute the sole known intramitochondrial mechanism for the catalytic removal of hydrogen and organic peroxides. dPrx3...
13.
Radyuk S, Michalak K, Klichko V, Benes J, Orr W
Biochim Biophys Acta
. 2010 Jul;
1800(11):1153-63.
PMID: 20600624
Background: Peroxiredoxins are redox-sensing enzymes with multiple cellular functions. Previously, we reported on the potent antioxidant function of Drosophila peroxiredoxin 5 (dPrx5). Studies with mammalian and human cells suggest that...
14.
Radyuk S, Michalak K, Klichko V, Benes J, Rebrin I, Sohal R, et al.
Biochem J
. 2009 Jan;
419(2):437-45.
PMID: 19128239
Peroxiredoxin 5 is a distinct isoform of the peroxiredoxin gene family. The antioxidative and anti-apoptotic functions of peroxiredoxin 5 have been extensively demonstrated in cell culture experiments. In the present...
15.
Radyuk S, Rebrin I, Luchak J, Michalak K, Klichko V, Sohal R, et al.
J Biol Chem
. 2008 Nov;
284(4):2266-74.
PMID: 19036725
GSH concentration is considerably lower in the nucleus than in the cytoplasm; however, it is significantly elevated during active cell proliferation. The main purpose of this study was to understand...
16.
Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster
Legan S, Rebrin I, Mockett R, Radyuk S, Klichko V, Sohal R, et al.
J Biol Chem
. 2008 Sep;
283(47):32492-9.
PMID: 18809674
The redox state of tissues tends to become progressively more prooxidizing during the aging process. The hypothesis tested in this study was that enhancement of reductive capacity by overexpression of...
17.
Klichko V, Radyuk S, Orr W
Arch Insect Biochem Physiol
. 2004 Apr;
56(1):34-50.
PMID: 15101064
Catalase represents one of the key antioxidant enzymes (AOE) in the metabolism of oxygen free radicals. A comprehensive analysis was brought to bear on establishing catalase gene expression profiles during...
18.
Radyuk S, Klichko V, Orr W
Gene
. 2004 Mar;
328:37-48.
PMID: 15019982
Cu,Zn-superoxide dismutase (SOD1) represents along with catalase the first coordinated line of defense against ROS and is found in all aerobic organisms. The dissection of the regulatory controls that drive...
19.
Klichko V, Miller J, Wu A, Popov S, Alibek K
Biochem Biophys Res Commun
. 2003 Apr;
303(3):855-62.
PMID: 12670489
A number of genes in Bacillus anthracis encode for proteins homologous to the membrane-damaging factors known as pathogenic determinants in different bacteria. B. anthracis, however, has been traditionally considered non-hemolytic,...