Vivian A Paschoal
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Explore the profile of Vivian A Paschoal including associated specialties, affiliations and a list of published articles.
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17
Citations
280
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Recent Articles
1.
Sun X, An Y, Paschoal V, de Souza C, Wang M, Vishvanath L, et al.
J Clin Invest
. 2023 Oct;
133(24).
PMID: 37856216
The G protein-coupled receptor 84 (GPR84), a medium-chain fatty acid receptor, has garnered attention because of its potential involvement in a range of metabolic conditions. However, the precise mechanisms underlying...
2.
Peng J, Yu L, Huang L, Paschoal V, Chu H, de Souza C, et al.
Mol Metab
. 2023 Sep;
78:101812.
PMID: 37777009
Objective: Sialic acid is a terminal monosaccharide of glycans in glycoproteins and glycolipids, and its derivation from glucose is regulated by the rate-limiting enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE). Although the...
3.
Joffin N, Gliniak C, Funcke J, Paschoal V, Crewe C, Chen S, et al.
Nat Metab
. 2022 Nov;
4(11):1474-1494.
PMID: 36329217
Iron is essential to many fundamental biological processes, but its cellular compartmentalization and concentration must be tightly controlled. Although iron overload can contribute to obesity-associated metabolic deterioration, the subcellular localization...
4.
de Souza C, Paschoal V, Sun X, Vishvanath L, Zhang Q, Shao M, et al.
J Clin Invest
. 2022 Sep;
132(21).
PMID: 36066975
The molecular mechanisms underlying obesity-induced increases in β cell mass and the resulting β cell dysfunction need to be elucidated further. Our study revealed that GPR92, expressed in islet macrophages,...
5.
Joffin N, Paschoal V, Gliniak C, Crewe C, Elnwasany A, Szweda L, et al.
Cell Stem Cell
. 2021 Feb;
28(4):702-717.e8.
PMID: 33539722
The adipose tissue stroma is a rich source of molecularly distinct stem and progenitor cell populations with diverse functions in metabolic regulation, adipogenesis, and inflammation. The ontology of these populations...
6.
Shan B, Shao M, Zhang Q, Hepler C, Paschoal V, Barnes S, et al.
Nat Metab
. 2020 Nov;
2(11):1332-1349.
PMID: 33139957
Chronic low-grade white adipose tissue (WAT) inflammation is a hallmark of metabolic syndrome in obesity. Here, we demonstrate that a subpopulation of mouse WAT perivascular (PDGFRβ) cells, termed fibro-inflammatory progenitors...
7.
Paschoal V, Oh D
Adipocyte
. 2020 Oct;
9(1):649-652.
PMID: 33108252
G Protein-coupled receptor 120 (GPR120; fatty acid receptor 4, FFAR4) and PPARγ agonists both lead to anti-inflammatory and insulin sensitizing effects despite signalling through distinct pathways. We recently reported the...
8.
Paschoal V, Walenta E, Talukdar S, Pessentheiner A, Osborn O, Hah N, et al.
Cell Metab
. 2020 May;
31(6):1173-1188.e5.
PMID: 32413335
G protein-coupled receptor 120 (GPR120) and PPARγ agonists each have insulin sensitizing effects. But whether these two pathways functionally interact and can be leveraged together to markedly improve insulin resistance...
9.
Crewe C, Zhu Y, Paschoal V, Joffin N, Ghaben A, Gordillo R, et al.
JCI Insight
. 2019 Jul;
5.
PMID: 31310592
The synthesis of lipid and sterol species through de novo lipogenesis (DNL) is regulated by two functionally overlapping but distinct transcription factors: the sterol regulatory element-binding proteins (SREBPs) and carbohydrate...
10.
Paschoal V, Belchior T, Amano M, Burgos-Silva M, Peixoto A, Magdalon J, et al.
Mol Nutr Food Res
. 2018 Jul;
62(17):e1800283.
PMID: 30001482
Scope: To test whether myeloid cells Tsc1 deletion and therefore constitutive activation of the nutrient sensor mTORC1 protects from high-fat diet (HFD)-induced obesity, glucose intolerance, and adipose tissue inflammation. Methods...