Visvanathan Ramamurthy
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Explore the profile of Visvanathan Ramamurthy including associated specialties, affiliations and a list of published articles.
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46
Citations
909
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Recent Articles
1.
Aliff H, Crockett A, Chrenek M, Nickerson J, Boatright J, Tseytlin O, et al.
Invest Ophthalmol Vis Sci
. 2025 Feb;
66(2):49.
PMID: 39969479
Purpose: To design and validate a cost-effective and titratable system capable of light-induced photoreceptor dysfunction and damage in pigmented mice. Methods: Two commonly used mouse strains in vision research, C57BL/6J...
2.
Sanzhaeva U, Boyd-Pratt H, Bender P, Saravanan T, Rhodes S, Guan T, et al.
Commun Biol
. 2024 Sep;
7(1):1146.
PMID: 39277687
Microtubules are essential for various cellular processes. The functional diversity of microtubules is attributed to the incorporation of various α- and β-tubulin isotypes encoded by different genes. In this work,...
3.
Sanzhaeva U, Wonsettler N, Rhodes S, Ramamurthy V
Sci Rep
. 2024 Sep;
14(1):20889.
PMID: 39244620
Microtubules, polymers of αβ-tubulin heterodimers, are essential for various cellular processes. The incorporation of different tubulin isotypes, each encoded by distinct genes, is proposed to contribute to the functional diversity...
4.
Yanardag S, Rhodes S, Saravanan T, Guan T, Ramamurthy V
Sci Rep
. 2024 May;
14(1):10498.
PMID: 38714794
Prominin 1 (PROM1) is a pentaspan transmembrane glycoprotein localized on the nascent photoreceptor discs. Mutations in PROM1 are linked to various retinal diseases. In this study, we assessed the role...
5.
Aljammal R, Saravanan T, Guan T, Rhodes S, Robichaux M, Ramamurthy V
Hum Mol Genet
. 2024 Feb;
33(9):802-817.
PMID: 38297980
Mutations in Cytosolic Carboxypeptidase-like Protein 5 (CCP5) are associated with vision loss in humans. To decipher the mechanisms behind CCP5-associated blindness, we generated a novel mouse model lacking CCP5. In...
6.
Moakedi F, Aljammal R, Poria D, Saravanan T, Rhodes S, Reid C, et al.
Hum Mol Genet
. 2023 Jun;
32(17):2735-2750.
PMID: 37384398
Phosphodiesterase-6 (PDE6) is the key phototransduction effector enzyme residing in the outer segment (OS) of photoreceptors. Cone PDE6 is a tetrameric protein consisting of two inhibitory subunits (γ') and two...
7.
Munezero D, Aliff H, Salido E, Saravanan T, Sanzhaeva U, Guan T, et al.
J Biol Chem
. 2023 May;
299(6):104809.
PMID: 37172722
Heat shock protein 90 (HSP90) is an abundant molecular chaperone that regulates the stability of a small set of proteins essential in various cellular pathways. Cytosolic HSP90 has two closely...
8.
Matalkah F, Rhodes S, Ramamurthy V, Stoilov P
PLoS One
. 2022 Oct;
17(10):e0274958.
PMID: 36215230
PROM1 (CD133, AC133) is a protein that is required for the maintenance of primary cilia. Mutation in the Prom1 gene in humans and animal models are associated with several forms...
9.
Matalkah F, Jeong B, Sheridan M, Horstick E, Ramamurthy V, Stoilov P
Commun Biol
. 2022 Sep;
5(1):1011.
PMID: 36153373
The Musashi proteins, MSI1 and MSI2, are conserved RNA binding proteins with a role in the maintenance and renewal of stem cells. Contrasting with this role, terminally differentiated photoreceptor cells...
10.
Phosphomimetic Mutations Impact Huntingtin Aggregation in the Presence of a Variety of Lipid Systems
Groover S, Beasley M, Ramamurthy V, Legleiter J
Biochemistry
. 2020 Dec;
59(49):4681-4693.
PMID: 33256402
Huntington's disease (HD) is a neurodegenerative disorder caused by the abnormal expansion of a polyglutamine (polyQ) tract in the first exon of the htt protein (htt). PolyQ expansion triggers the...